SLC6A8 and CD59

Number of citations of the paper that reports this interaction (PMID 12219031)
1

Data Source:
HPRD (in vivo)

		SLC6A8	CD59
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 8	CD59 molecule, complement regulatory protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Vesicle Sarcolemma Compact Myelin Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Creatine Transmembrane Transporter Activity Creatine:sodium Symporter Activity Neurotransmitter:sodium Symporter Activity	Complement Binding Protein Binding
	Biological Process	Creatine Metabolic Process Transport Sodium Ion Transport Neurotransmitter Transport Muscle Contraction Biological_process Creatine Transport Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Creatine Transmembrane Transport	Cell Activation Negative Regulation Of Activation Of Membrane Attack Complex Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response
Pathways		Metabolism of amino acids and derivatives Creatine metabolism	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs		Creatine
Diseases
GWAS
Protein-Protein Interactions		1 interactors: CD59	12 interactors: C8A C9 CD2 CD8A CD9 EGFR GNAI3 NCR1 NCR3 SLC6A8 SMAD4 SRC
Entrez ID		6535	966
HPRD ID		02073	00117
Ensembl ID		ENSG00000130821
Uniprot IDs		P48029 Q59EV7	E9PI80 P13987 Q6FHM9
PDB IDs			1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Complement Activation Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of T Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune Response Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Inflammatory Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of Protein Processing Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Cell Activation Regulation Of Body Fluid Levels Wound Healing Regulation Of Cell Adhesion Cell Activation Response To Wounding	Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Immune Response Defense Response Immune System Process Complement Activation, Alternative Pathway Positive Regulation Of Protein Transport Immune Response Membrane Organization Blood Coagulation Hemostasis Positive Regulation Of Immune System Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Cytolysis Single Organismal Cell-cell Adhesion Platelet Activation Regulation Of Complement Activation Regulation Of Body Fluid Levels Wound Healing Cell Adhesion Regulation Of Protein Transport Positive Regulation Of Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Establishment Of Protein Localization Leukocyte Mediated Immunity Adaptive Immune Response Response To Wounding Regulation Of Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transport Natural Killer Cell Activation Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Innate Immune Response Alkanesulfonate Metabolic Process Cytotoxic T Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Myeloid Dendritic Cell Activation Regulation Of Acute Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Positive Regulation Of Cytokine Secretion Regulation Of Protein Processing Positive Regulation Of Protein Import Into Nucleus Lymphocyte Activation
Tagcloud ?		accomplished ag490 bath brefeldin carrier clamp coexpressing coexpression concentrative crea creat creatine crna downregulates electrode electrogenic injected insertion inward jak2 k882e oocytes participates presumably sglt1 transporter v617f xenopus	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Difference) ?		accomplished ag490 bath brefeldin carrier clamp coexpressing coexpression concentrative crea creat creatine crna downregulates electrode electrogenic injected insertion inward jak2 k882e oocytes participates presumably sglt1 transporter v617f xenopus	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Intersection) ?