CLDN4 and EPHA2

Number of citations of the paper that reports this interaction (PMID 16236711)
35

Data Source:
HPRD (in vivo)

		CLDN4	EPHA2
Gene Name		claudin 4	EPH receptor A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Signal Transduction Female Pregnancy Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Response To Progesterone Establishment Of Skin Barrier	Skeletal System Development Angiogenesis Vasculogenesis Osteoblast Differentiation Cell Adhesion Multicellular Organismal Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Viral Process Cell Migration Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Activation Of Rac GTPase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs			Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		4 interactors: EPHA2 SHBG TJP1 WNK4	30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A
Entrez ID		1364	1969
HPRD ID		04218	01494
Ensembl ID		ENSG00000189143	ENSG00000142627
Uniprot IDs		O14493 Q75L80	P29317
PDB IDs			1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Involved In Cell-cell Junction Organization Primary Spermatocyte Growth Notochord Cell Development Epithelium Development Epithelial Cell Development Distal Tubule Morphogenesis Axial Mesoderm Formation Response To Magnetism Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Notochord Formation Axial Mesoderm Morphogenesis Lens Fiber Cell Morphogenesis Establishment Of Endothelial Intestinal Barrier Tissue Development Axial Mesoderm Development Epithelial Tube Morphogenesis Cell Development Intracellular Signal Transduction Anatomical Structure Development Notochord Morphogenesis Tube Morphogenesis Renal Absorption Distal Tubule Development Activation Of Rac GTPase Activity Negative Regulation Of Vascular Permeability Morphogenesis Of An Epithelium Developmental Process Epithelial Cell Differentiation Lens Fiber Cell Development Post-anal Tail Morphogenesis Mammary Gland Epithelial Cell Proliferation Notochord Development Anatomical Structure Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Localization To Plasma Membrane Tissue Morphogenesis Establishment Of Endothelial Barrier Hippo Signaling Lens Morphogenesis In Camera-type Eye Tube Development Regulation Of Vascular Permeability Lens Fiber Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Protein Kinase B Signaling Activation Of Rho GTPase Activity Protein Kinase B Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Locomotion Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Neuron Projection Development Cell Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis Neurotrophin Signaling Pathway Neuron Development Cell Morphogenesis Signal Transduction Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Signaling Regulation Of Signaling Cell Communication Fc Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Regulation Of ERBB Signaling Pathway Cell Motility Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Catalytic Activity Neurogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Regulation Of Body Fluid Levels
Tagcloud ?		acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim	abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Difference) ?		acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim	abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Intersection) ?