CLDN4 and TJP1

Number of citations of the paper that reports this interaction (PMID 10601346)
178

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CLDN4	TJP1
Gene Name		claudin 4	tight junction protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Identical Protein Binding	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Signal Transduction Female Pregnancy Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Response To Progesterone Establishment Of Skin Barrier	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		4 interactors: EPHA2 SHBG TJP1 WNK4	38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		1364	7082
HPRD ID		04218	03002
Ensembl ID		ENSG00000189143	ENSG00000104067
Uniprot IDs		O14493 Q75L80	G3V1L9 Q07157 Q6MZU1
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Involved In Cell-cell Junction Organization Primary Spermatocyte Growth Notochord Cell Development Epithelium Development Epithelial Cell Development Distal Tubule Morphogenesis Axial Mesoderm Formation Response To Magnetism Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Notochord Formation Axial Mesoderm Morphogenesis Lens Fiber Cell Morphogenesis Establishment Of Endothelial Intestinal Barrier Tissue Development Axial Mesoderm Development Epithelial Tube Morphogenesis Cell Development Intracellular Signal Transduction Anatomical Structure Development Notochord Morphogenesis Tube Morphogenesis Renal Absorption Distal Tubule Development Activation Of Rac GTPase Activity Negative Regulation Of Vascular Permeability Morphogenesis Of An Epithelium Developmental Process Epithelial Cell Differentiation Lens Fiber Cell Development Post-anal Tail Morphogenesis Mammary Gland Epithelial Cell Proliferation Notochord Development Anatomical Structure Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Localization To Plasma Membrane Tissue Morphogenesis Establishment Of Endothelial Barrier Hippo Signaling Lens Morphogenesis In Camera-type Eye Tube Development Regulation Of Vascular Permeability Lens Fiber Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Protein Kinase B Signaling Activation Of Rho GTPase Activity Protein Kinase B Signaling	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling
Tagcloud ?		acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Difference) ?		acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Intersection) ?