CLDN4 and FFAR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN4	FFAR2
Description		claudin 4	free fatty acid receptor 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction Anchoring Junction	Plasma Membrane Membrane Cell Projection
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Cell Adhesion Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Monoatomic Ion Transmembrane Transport Establishment Of Skin Barrier Renal Absorption Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Paracellular Transport Chloride Transmembrane Transport	Leukocyte Chemotaxis Involved In Inflammatory Response Immune System Process Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Insulin Secretion Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-8 Production Glucose Homeostasis Fat Cell Differentiation Negative Regulation Of Insulin Secretion Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Ligand-gated Ion Channel Signaling Pathway
Pathways		Tight junction interactions	G alpha (q) signalling events Free fatty acid receptors
Drugs			GLPG-0974
Diseases
GWAS			Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		19 interacting genes: AQP6 ARL13B CLEC14A EPHA2 FAM209A FFAR2 GJA8 GOLM1 HSD17B13 ICAM3 SHBG SLC71A2 SYT2 TJP1 TMEM237 TMEM52B TRIM59 TSPO2 WNK4	120 interacting genes: AGPAT4 AGTRAP ALOX5AP ANKRD46 APOD ARLN ATP13A1 ATP6V0C BMP10 BNIP3 BTN2A2 C11orf24 C3orf52 CACNG1 CATSPERH CBLIF CCDC167 CD82 CDIPT CFHR5 CGRRF1 CLDN4 CLDND2 CLEC1A CMTM5 CMTM7 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB5R2 DERL1 EDDM3B EMC6 EMP1 ERG28 FAM20B FAM3C FAXDC2 FCER1G FIS1 FXYD3 FXYD6 FZD7 GALNT15 GJB2 GNAO1 GNAQ GPR37L1 GUCA2A GYPA IFITM3 IGF1R IGFBP5 KRT1 KTN1 LAPTM4A LAT LEPROTL1 LHFPL5 LPAR3 MALL MS4A13 NAT8 NIPAL4 NKG7 NRM NSG1 NUCB2 OR10AG1 PEX16 PLP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SACM1L SCGB1D1 SELENOK SERP2 SLC30A2 SLC35B4 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A9 SLC41A1 SLC61A1 SMAGP SMCO4 SMIM1 STRIT1 STX8 SYNDIG1 TEX264 TM4SF4 TMEM11 TMEM120B TMEM128 TMEM144 TMEM147 TMEM203 TMEM218 TMEM229B TMEM239 TMEM243 TMEM60 TMEM86A TMEM86B TMEM97 TNF TSPO2 UNC50 UPK1B YIF1A YIPF2 YIPF6
Entrez ID		1364	2867
HPRD ID		04218	04824
Ensembl ID		ENSG00000189143	ENSG00000126262
Uniprot IDs		O14493 Q75L80	C6KYL4 O15552
PDB IDs		5B2G 7KP4 7TDM 7TDN 8U4V 8U5B 9CMH 9CMI	8J22 8J23 8J24 8T3S 9K1D
Enriched GO Terms of Interacting Partners?		Membrane	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Bleb Assembly Alkenylglycerophosphocholine Hydrolase Activity Transmembrane Transport
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