SLC3A2 and SLC7A8

Number of citations of the paper that reports this interaction (PubMedID 11311135)
18

Data Source:
HPRD (in vitro)

		SLC3A2	SLC7A8
Description		solute carrier family 3 member 2	solute carrier family 7 member 8
Image
GO Annotations	Cellular Component	Nucleoplasm Lysosome Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Melanosome Neuronal Cell Body Apical Pole Of Neuron Synapse Extracellular Exosome Anchoring Junction Amino Acid Transport Complex	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane
	Molecular Function	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Exogenous Protein Binding	Protein Binding Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Antiporter Activity Thyroid Hormone Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Peptide Antigen Binding Protein Heterodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Isoleucine Transport L-leucine Transport Methionine Transport Phenylalanine Transport Proline Transport Tryptophan Transport Tyrosine Transport Valine Transport Response To Exogenous DsRNA Symbiont Entry Into Host Cell Thyroid Hormone Transport L-histidine Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Amino Acid Transmembrane Transport Amino Acid Transport Neutral Amino Acid Transport L-amino Acid Transport Glycine Transport L-leucine Transport Tryptophan Transport Valine Transport Proline Transmembrane Transport Transmembrane Transport Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism	Basigin interactions Amino acid transport across the plasma membrane
Drugs			Phenylalanine Alanine
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		18 interacting genes: CCR4 CEBPA EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 KLHL20 MTNR1B NPSR1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL	26 interacting genes: ABHD16A AGPAT4 AQP6 COMT DERL1 FXYD6-FXYD2 MFF NDUFA3 NINJ2 REEP4 SIGLEC5 SLC25A46 SLC30A2 SLC33A2 SLC3A1 SLC3A2 SMPD2 SNORC SYCE1L SYNJ2BP TMEM14B TMEM208 TMEM60 TMEM65 YIPF1 YIPF6
Entrez ID		6520	23428
HPRD ID		01148	11971
Ensembl ID		ENSG00000168003	ENSG00000092068
Uniprot IDs		P08195	Q53EM9 Q9UHI5
PDB IDs		2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V 7B00 7CCS 7CMH 7CMI 7DF1 7DSK 7DSL 7DSN 7DSQ 7EPZ 7P9U 7P9V 8A6L 8G0M 8IDA 8J8L 8J8M 8KDD 8KDF 8KDG 8KDH 8KDI 8KDJ 8KDN 8KDO 8KDP 8QEY 8WNS 8WNT 8WNY 8X0W 8XPU 8YLP	7B00 7CMH 7CMI 8A6L
Enriched GO Terms of Interacting Partners?		L-amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transport L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Amino Acid Transmembrane Transport Negative Regulation Of Programmed Cell Death Amino Acid Transport Branched-chain Amino Acid Transport L-leucine Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Alanine Transport Neutral L-amino Acid Transmembrane Transporter Activity Transmembrane Transporter Activity Negative Regulation Of Apoptotic Process Organic Cation Transport L-leucine Import Across Plasma Membrane Microvillus Membrane Liver Development Response To Amino Acid Regulation Of Apoptotic Process Amino Acid Import Across Plasma Membrane Carboxylic Acid Transport Organic Acid Transport Valine Transport Regulation Of Programmed Cell Death L-leucine Transmembrane Transporter Activity Tryptophan Transport Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Organic Anion Transport Negative Regulation Of Catabolic Process Basal Plasma Membrane Aromatic Amino Acid Transport Thyroid Hormone Transport Organic Cation Transmembrane Transporter Activity Animal Organ Development Glycine Transport Negative Regulation Of Vasoconstriction Cellular Response To Amino Acid Stimulus Virus Receptor Activity Sulfur Amino Acid Transport Basolateral Plasma Membrane Vascular Process In Circulatory System Neuropeptide Signaling Pathway Learning Or Memory Gland Development Neuropeptide Receptor Activity Basic Amino Acid Transport Response To Cytokine	Membrane Golgi Trans Cisterna Golgi Medial Cisterna Sulfur Amino Acid Transport Mitochondrial Fission Mitochondrial Outer Membrane Basic Amino Acid Transport
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