SLC3A2 and ICAM1

Number of citations of the paper that reports this interaction (PMID 12716892)
7

Data Source:
HPRD (in vivo)

		SLC3A2	ICAM1
Gene Name		solute carrier family 3 (amino acid transporter heavy chain), member 2	intercellular adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Melanosome Extracellular Vesicular Exosome	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome
	Molecular Function	Double-stranded RNA Binding Catalytic Activity Calcium:sodium Antiporter Activity Protein Binding Neutral Amino Acid Transmembrane Transporter Activity Cation Binding Poly(A) RNA Binding	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding
	Biological Process	Carbohydrate Metabolic Process Ion Transport Calcium Ion Transport Amino Acid Transport Blood Coagulation Tryptophan Transport Cell Growth Sodium Ion Transmembrane Transport Response To Exogenous DsRNA Leukocyte Migration Transmembrane Transport Leucine Import	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane SLC-mediated transmembrane transport Basigin interactions Cell surface interactions at the vascular wall	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs			Natalizumab Hyaluronan
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)
Protein-Protein Interactions		11 interactors: EGFR FAM57A HNRNPD ICAM1 ITGB1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 VHL	12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN
Entrez ID		6520	3383
HPRD ID		01148	00996
Ensembl ID		ENSG00000168003	ENSG00000090339
Uniprot IDs		J3KPF3 P08195	B4DQW5 E7ESS4 P05362
PDB IDs		2DH2 2DH3	1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell Migration Cell Motility Amino Acid Transmembrane Transport Amino Acid Transport Locomotion Neutral Amino Acid Transport Blood Coagulation Hemostasis L-alpha-amino Acid Transmembrane Transport Movement Of Cell Or Subcellular Component Regulation Of Body Fluid Levels Wound Healing Carboxylic Acid Transport Organic Acid Transport Response To Wounding Immune System Process Response To Stress Anion Transmembrane Transport Organic Anion Transport Anion Transport Cell Adhesion Mediated By Integrin Single Organismal Cell-cell Adhesion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Vasoconstriction Ion Transmembrane Transport Response To Gonadotropin Cell Activation Viral Entry Into Host Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Entry Into Host Cell Rhythmic Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Migration Chemical Homeostasis Positive Regulation Of Cell Motility Response To Organic Cyclic Compound Positive Regulation Of Cellular Component Movement Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Locomotion Negative Regulation Of Apoptotic Process Transmembrane Transport Negative Regulation Of Programmed Cell Death Ion Transport Alkanesulfonate Metabolic Process Response To Sulfur Dioxide D-alanine Transport	Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation
Tagcloud ?		adenocarcinoma anchorage approved braf cd74 consisting constitutively driver druggable erbb4 exclusively ezr fusion fusions her3 ima imas kiaa1468 kras mucinous mutually nih3t3 nrg1 oncogenic ret sequencing transcriptome trim24 tumorigenicity	baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Difference) ?		adenocarcinoma anchorage approved braf cd74 consisting constitutively driver druggable erbb4 exclusively ezr fusion fusions her3 ima imas kiaa1468 kras mucinous mutually nih3t3 nrg1 oncogenic ret sequencing transcriptome trim24 tumorigenicity	baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Intersection) ?