SLC3A2 and EBP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC3A2	EBP
Description		solute carrier family 3 member 2	EBP cholestenol delta-isomerase
Image
GO Annotations	Cellular Component	Nucleoplasm Lysosome Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Melanosome Neuronal Cell Body Apical Pole Of Neuron Synapse Extracellular Exosome Anchoring Junction Amino Acid Transport Complex	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Exogenous Protein Binding	C-8 Sterol Isomerase Activity Steroid Delta-isomerase Activity Protein Binding Hydrolase Activity Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Identical Protein Binding Cholestenol Delta-isomerase Activity
	Biological Process	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Isoleucine Transport L-leucine Transport Methionine Transport Phenylalanine Transport Proline Transport Tryptophan Transport Tyrosine Transport Valine Transport Response To Exogenous DsRNA Symbiont Entry Into Host Cell Thyroid Hormone Transport L-histidine Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Hemopoiesis Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Ossification Involved In Bone Maturation
Pathways		Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism	Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs			Tamoxifen
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: CCR4 CEBPA EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 KLHL20 MTNR1B NPSR1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL	172 interacting genes: ABHD16A ANKRD46 APP AQP6 ARL13B ARL6IP6 ARLN ARV1 ATP13A1 BMP10 BNIP3 BTN2A2 C2 C2CD2L C5 C5orf46 CCDC167 CCL4L2 CD40 CD69 CD81 CDIPT CHODL CLDND2 CREB3 CREB3L1 CYB561 CYB5B CYP4F2 DEFB103A DEFB103B DEFB127 DNAJC30 EBPL EMC6 EMP1 ERG28 ERGIC3 ESRRG FA2H FAM209A FAXDC2 FCER1G FETUB FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 GIMAP1 GIMAP5 GJB2 GJB6 GLP1R GOSR2 GPR152 HMOX2 HSD17B13 IER3IP1 INSIG2 JAGN1 LDLRAD1 LEMD1 LPCAT2 LRP10 LRRC59 LTC4S MFSD6 MITF MMP14 MS4A13 MTNR1B NAT8 NDUFA3 NDUFB11 NEU1 NINJ1 NINJ2 NKG7 ODF4 ORMDL1 ORMDL2 ORMDL3 OTOP3 PLLP PLP2 PLPP6 PMP22 PNLIPRP1 PTPN9 PVR RNF152 RTP2 RUSF1 SACM1L SCAMP4 SEC22B SERP1 SERP2 SFXN5 SLC10A6 SLC35G1 SLC3A2 SLC41A2 SMAGP SMCO4 SMIM1 SMIM3 SNORC STX12 STX1B STX5 STX6 STX7 STX8 SYNGR1 SYNJ2BP SYS1 TBC1D20 THBD TIMM23 TLCD1 TLCD4 TMBIM6 TMEM100 TMEM11 TMEM120B TMEM140 TMEM147 TMEM14B TMEM14C TMEM167B TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM239 TMEM242 TMEM243 TMEM254 TMEM31 TMEM42 TMEM51 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMIE TRARG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBIAD1 UNC50 UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB VMA12 YIF1A YIPF1 YIPF4 YIPF6 ZDHHC24 ZFPL1
Entrez ID		6520	10682
HPRD ID		01148	02192
Ensembl ID		ENSG00000168003	ENSG00000147155
Uniprot IDs		P08195	A0A024QYX0 Q15125
PDB IDs		2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V 7B00 7CCS 7CMH 7CMI 7DF1 7DSK 7DSL 7DSN 7DSQ 7EPZ 7P9U 7P9V 8A6L 8G0M 8IDA 8J8L 8J8M 8KDD 8KDF 8KDG 8KDH 8KDI 8KDJ 8KDN 8KDO 8KDP 8QEY 8WNS 8WNT 8WNY 8X0W 8XPU 8YLP	6OHT 6OHU 8W0R 8W0S
Enriched GO Terms of Interacting Partners?		L-amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transport L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Amino Acid Transmembrane Transport Negative Regulation Of Programmed Cell Death Amino Acid Transport Branched-chain Amino Acid Transport L-leucine Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Alanine Transport Neutral L-amino Acid Transmembrane Transporter Activity Transmembrane Transporter Activity Negative Regulation Of Apoptotic Process Organic Cation Transport L-leucine Import Across Plasma Membrane Microvillus Membrane Liver Development Response To Amino Acid Regulation Of Apoptotic Process Amino Acid Import Across Plasma Membrane Carboxylic Acid Transport Organic Acid Transport Valine Transport Regulation Of Programmed Cell Death L-leucine Transmembrane Transporter Activity Tryptophan Transport Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Organic Anion Transport Negative Regulation Of Catabolic Process Basal Plasma Membrane Aromatic Amino Acid Transport Thyroid Hormone Transport Organic Cation Transmembrane Transporter Activity Animal Organ Development Glycine Transport Negative Regulation Of Vasoconstriction Cellular Response To Amino Acid Stimulus Virus Receptor Activity Sulfur Amino Acid Transport Basolateral Plasma Membrane Vascular Process In Circulatory System Neuropeptide Signaling Pathway Learning Or Memory Gland Development Neuropeptide Receptor Activity Basic Amino Acid Transport Response To Cytokine	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Endomembrane System Cellular Localization Organelle Localization By Membrane Tethering SNARE Binding Vesicle Organization Membrane Docking Establishment Of Protein Localization Vesicle Docking Intracellular Transport Golgi Membrane Establishment Of Localization In Cell Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNARE Complex Assembly Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Secretion By Cell Chemical Homeostasis Negative Regulation Of Sphingolipid Biosynthetic Process Protein Transport Serine Palmitoyltransferase Complex Exocytosis Establishment Of Protein Localization To Membrane Endoplasmic Reticulum Unfolded Protein Response Sterol Biosynthetic Process Transport Vesicle Regulation Of Cellular Localization Alkenylglycerophosphocholine Hydrolase Activity Intracellular Chemical Homeostasis Host-mediated Activation Of Viral Genome Replication Golgi Apparatus Syntaxin Binding Nuclear Inner Membrane Host-mediated Perturbation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Intracellular Protein Localization Phagocytic Vesicle
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