SLC3A2 and SLC7A7

Number of citations of the paper that reports this interaction (PubMedID 9878049)
39

Data Source:
HPRD (in vitro)

		SLC3A2	SLC7A7
Description		solute carrier family 3 member 2	solute carrier family 7 member 7
Image
GO Annotations	Cellular Component	Nucleoplasm Lysosome Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Melanosome Neuronal Cell Body Apical Pole Of Neuron Synapse Extracellular Exosome Anchoring Junction Amino Acid Transport Complex	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Exogenous Protein Binding	Protein Binding Basic Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Isoleucine Transport L-leucine Transport Methionine Transport Phenylalanine Transport Proline Transport Tryptophan Transport Tyrosine Transport Valine Transport Response To Exogenous DsRNA Symbiont Entry Into Host Cell Thyroid Hormone Transport L-histidine Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Regulation Of Arginine Metabolic Process Amino Acid Transmembrane Transport Amino Acid Transport L-leucine Transport Transmembrane Transport L-arginine Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways		Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism	Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Drugs			Fluciclovine (18F)
Diseases			Lysinuric protein intolerance (LPI)
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Intraocular pressure ( 30591961) Iris color (b* coordinate) ( 30895295) Psychological resilience (outcome-based) in high deployment stress exposure ( 31081985) Resting-state electroencephalogram vigilance ( 29703947) Type 2 diabetes ( 30297969)
Interacting Genes		18 interacting genes: CCR4 CEBPA EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 KLHL20 MTNR1B NPSR1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL	2 interacting genes: NEDD4L SLC3A2
Entrez ID		6520	9056
HPRD ID		01148	04667
Ensembl ID		ENSG00000168003	ENSG00000155465
Uniprot IDs		P08195	A0A0S2Z502 Q9UM01
PDB IDs		2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V 7B00 7CCS 7CMH 7CMI 7DF1 7DSK 7DSL 7DSN 7DSQ 7EPZ 7P9U 7P9V 8A6L 8G0M 8IDA 8J8L 8J8M 8KDD 8KDF 8KDG 8KDH 8KDI 8KDJ 8KDN 8KDO 8KDP 8QEY 8WNS 8WNT 8WNY 8X0W 8XPU 8YLP	8XXI 8XYJ 8YLP
Enriched GO Terms of Interacting Partners?		L-amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transport L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Amino Acid Transmembrane Transport Negative Regulation Of Programmed Cell Death Amino Acid Transport Branched-chain Amino Acid Transport L-leucine Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Alanine Transport Neutral L-amino Acid Transmembrane Transporter Activity Transmembrane Transporter Activity Negative Regulation Of Apoptotic Process Organic Cation Transport L-leucine Import Across Plasma Membrane Microvillus Membrane Liver Development Response To Amino Acid Regulation Of Apoptotic Process Amino Acid Import Across Plasma Membrane Carboxylic Acid Transport Organic Acid Transport Valine Transport Regulation Of Programmed Cell Death L-leucine Transmembrane Transporter Activity Tryptophan Transport Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Organic Anion Transport Negative Regulation Of Catabolic Process Basal Plasma Membrane Aromatic Amino Acid Transport Thyroid Hormone Transport Organic Cation Transmembrane Transporter Activity Animal Organ Development Glycine Transport Negative Regulation Of Vasoconstriction Cellular Response To Amino Acid Stimulus Virus Receptor Activity Sulfur Amino Acid Transport Basolateral Plasma Membrane Vascular Process In Circulatory System Neuropeptide Signaling Pathway Learning Or Memory Gland Development Neuropeptide Receptor Activity Basic Amino Acid Transport Response To Cytokine	Import Across Plasma Membrane Apical Pole Of Neuron Isoleucine Transport L-histidine Transport Apical Plasma Membrane Exogenous Protein Binding Methionine Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Phenylalanine Transport Amino Acid Transport Complex L-alanine Transmembrane Transport Aromatic Amino Acid Transmembrane Transporter Activity Valine Transport Tryptophan Transport L-alanine Import Across Plasma Membrane Tyrosine Transport Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis L-alanine Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Caveolin-mediated Endocytosis L-alanine Transport Aromatic Amino Acid Transport Metal Ion Transport Branched-chain Amino Acid Transport L-leucine Transport Proline Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transmembrane Transport Import Into Cell Thyroid Hormone Transport Negative Regulation Of Protein Localization To Cell Surface Regulation Of Potassium Ion Export Across Plasma Membrane Alanine Transport Sulfur Amino Acid Transport Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transport Ventricular Cardiac Muscle Cell Action Potential Neutral L-amino Acid Transmembrane Transporter Activity Receptor Catabolic Process Basic Amino Acid Transport Positive Regulation Of Dendrite Extension Negative Regulation Of Potassium Ion Transmembrane Transport Monoatomic Ion Transport Sodium Ion Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transport Sodium Channel Regulator Activity Amino Acid Import Across Plasma Membrane
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