SLC3A2 and ITGB1

Number of citations of the paper that reports this interaction (PMID 12181350)
13

Data Source:
HPRD (in vivo, in vitro)

		SLC3A2	ITGB1
Gene Name		solute carrier family 3 (amino acid transporter heavy chain), member 2	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Melanosome Extracellular Vesicular Exosome	Acrosomal Vesicle Ruffle Basement Membrane Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Hemidesmosome Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Recycling Endosome Extracellular Vesicular Exosome Invadopodium Membrane Synaptic Membrane
	Molecular Function	Double-stranded RNA Binding Catalytic Activity Calcium:sodium Antiporter Activity Protein Binding Neutral Amino Acid Transmembrane Transporter Activity Cation Binding Poly(A) RNA Binding	Virus Receptor Activity Glycoprotein Binding Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Peptide Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Alpha-actinin Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Carbohydrate Metabolic Process Ion Transport Calcium Ion Transport Amino Acid Transport Blood Coagulation Tryptophan Transport Cell Growth Sodium Ion Transmembrane Transport Response To Exogenous DsRNA Leukocyte Migration Transmembrane Transport Leucine Import	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Cell Fate Specification Tissue Homeostasis Cell Migration Involved In Sprouting Angiogenesis Cellular Calcium Ion Homeostasis Cellular Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Response To Virus Regulation Of Collagen Catabolic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Activity Viral Process Cell Migration Formation Of Radial Glial Scaffolds B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Projection Organization Cell-substrate Adhesion Protein Transport Within Lipid Bilayer Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Cell Junction Assembly Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Response To Drug Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAPK Cascade Sarcomere Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Maternal Process Involved In Female Pregnancy Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Vitamin D Cellular Response To Ionizing Radiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane SLC-mediated transmembrane transport Basigin interactions Cell surface interactions at the vascular wall	Platelet Adhesion to exposed collagen Axon guidance Elastic fibre formation L1CAM interactions Molecules associated with elastic fibres Laminin interactions ECM proteoglycans Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell junction organization Signal transduction by L1 Semaphorin interactions Other semaphorin interactions Non-integrin membrane-ECM interactions Basigin interactions Cell surface interactions at the vascular wall Syndecan interactions CHL1 interactions Integrin cell surface interactions Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS			Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		11 interactors: EGFR FAM57A HNRNPD ICAM1 ITGB1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 VHL	67 interactors: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EPS8 FBLN1 FBXO2 FHL2 FLNA FLNB FLT4 FN1 GNB2L1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 NCKIPSD NF2 NME1 NMRK2 PDHB PLAUR PRKCA PRKCE PTK2 PXN RAB25 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 UPF2 VCAM1 VCAN YWHAB
Entrez ID		6520	3688
HPRD ID		01148	00628
Ensembl ID		ENSG00000168003	ENSG00000150093
Uniprot IDs		J3KPF3 P08195	P05556
PDB IDs		2DH2 2DH3	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell Migration Cell Motility Amino Acid Transmembrane Transport Amino Acid Transport Locomotion Neutral Amino Acid Transport Blood Coagulation Hemostasis L-alpha-amino Acid Transmembrane Transport Movement Of Cell Or Subcellular Component Regulation Of Body Fluid Levels Wound Healing Carboxylic Acid Transport Organic Acid Transport Response To Wounding Immune System Process Response To Stress Anion Transmembrane Transport Organic Anion Transport Anion Transport Cell Adhesion Mediated By Integrin Single Organismal Cell-cell Adhesion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Vasoconstriction Ion Transmembrane Transport Response To Gonadotropin Cell Activation Viral Entry Into Host Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Entry Into Host Cell Rhythmic Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Migration Chemical Homeostasis Positive Regulation Of Cell Motility Response To Organic Cyclic Compound Positive Regulation Of Cellular Component Movement Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Locomotion Negative Regulation Of Apoptotic Process Transmembrane Transport Negative Regulation Of Programmed Cell Death Ion Transport Alkanesulfonate Metabolic Process Response To Sulfur Dioxide D-alanine Transport	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell-matrix Adhesion Cell-substrate Adhesion Wound Healing Response To Wounding Regulation Of Body Fluid Levels Multicellular Organismal Development Movement Of Cell Or Subcellular Component Anatomical Structure Development Locomotion System Development Developmental Process Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Cell Migration Leukocyte Migration Cell Motility Signal Transduction Cell Junction Assembly Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Signaling Response To Stimulus Positive Regulation Of Locomotion Regulation Of Cell Motility Cell Communication Cell Activation Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Platelet Activation Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Process Cell Morphogenesis Response To Stress
Tagcloud ?		adenocarcinoma anchorage approved braf cd74 consisting constitutively driver druggable erbb4 exclusively ezr fusion fusions her3 ima imas kiaa1468 kras mucinous mutually nih3t3 nrg1 oncogenic ret sequencing transcriptome trim24 tumorigenicity	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?		adenocarcinoma anchorage approved braf cd74 consisting constitutively driver druggable erbb4 exclusively ezr fusion fusions her3 ima imas kiaa1468 kras mucinous mutually nih3t3 nrg1 oncogenic ret sequencing transcriptome trim24 tumorigenicity	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Intersection) ?