GPR35 and SLC31A2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR35	SLC31A2
Description		G protein-coupled receptor 35	solute carrier family 31 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Recycling Endosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity	Copper Ion Transmembrane Transporter Activity Protein Binding
	Biological Process	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Copper Ion Import Copper Ion Transmembrane Transport Regulation Of Copper Ion Transmembrane Transport
Pathways		Class A/1 (Rhodopsin-like receptors)
Drugs		Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	9 interacting genes: BNIP3 F2RL1 GPR35 HTR2B OPRL1 RAMP1 RAMP2 RAMP3 VKORC1
Entrez ID		2859	1318
HPRD ID		16003	04365
Ensembl ID		ENSG00000178623	ENSG00000136867
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	O15432 Q53X94
PDB IDs		8H8J
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport	Amylin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Adrenomedullin Receptor Signaling Pathway Coreceptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Ion Transport Receptor Internalization G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Signal Transduction G-protein Alpha-subunit Binding Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Receptor Complex Positive Regulation Of Protein-containing Complex Disassembly Metal Ion Transport Protein Localization To Cell Periphery Membrane Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Monoatomic Cation Transport Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Circulatory System Process Positive Regulation Of Renin Secretion Into Blood Stream Nociceptin Receptor Activity Protein Localization To Membrane Calcitonin Gene-related Peptide Binding Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Cellular Response To Hormone Stimulus Regulation Of Biological Quality Monoatomic Ion Transport Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Adrenomedullin Binding CGRP Receptor Complex Amylin Receptor Complex 3 Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
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