GPR35 and NPC1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GPR35	NPC1
Description		G protein-coupled receptor 35	NPC intracellular cholesterol transporter 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Late Endosome Membrane Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity	Virus Receptor Activity Transmembrane Signaling Receptor Activity Lipid Transporter Activity Protein Binding Cholesterol Binding Signaling Receptor Activity Cholesterol Transfer Activity
	Biological Process	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity	Liver Development Protein Glycosylation Lipid Metabolic Process Lipid Transport Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Steroid Metabolic Process Cholesterol Metabolic Process Bile Acid Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cholesterol Storage Programmed Cell Death Sterol Transport Sterol Metabolic Process Macroautophagy Negative Regulation Of Macroautophagy Neurogenesis Intestinal Cholesterol Absorption Cholesterol Transport Membrane Raft Organization Intracellular Lipid Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Response To Cadmium Ion Symbiont Entry Into Host Cell Establishment Of Localization In Cell Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Cyclodextrin Metabolic Process
Pathways		Class A/1 (Rhodopsin-like receptors)	LDL clearance
Drugs		Furosemide Pyrantel Kynurenic Acid
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Walking pace ( 33128006) White blood cell count ( 27863252)
Interacting Genes		58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	6 interacting genes: BUD31 DYRK1A GPR35 MC4R MTDH VPS4A
Entrez ID		2859	4864
HPRD ID		16003	09622
Ensembl ID		ENSG00000178623	ENSG00000141458
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	O15118
PDB IDs		8H8J	3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V 8EUS 9DZ2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport	Positive Regulation Of Viral Life Cycle Transcription Coactivator Activity Histone H3T45 Kinase Activity Response To Melanocyte-stimulating Hormone Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Positive Regulation Of Viral Process Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Contractile Ring Contraction Regulation Of Viral Life Cycle Melanocyte-stimulating Hormone Receptor Activity Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Viral Process Viral Translation Viral Life Cycle Viral Process Mitotic Cytokinesis Checkpoint Signaling Centrosome Negative Regulation Of Heterochromatin Formation Melanocortin Receptor Activity Cytokine Precursor Processing Biological Process Involved In Interaction With Host Nerve Growth Factor Binding Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Intercellular Canaliculus Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Eating Behavior Heparan Sulfate Binding Regulation Of Heterochromatin Formation Signal Peptide Processing RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Mitotic Nuclear Membrane Reassembly
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