ROPN1 and GNL3L

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ROPN1	GNL3L
Name		rhophilin associated tail protein 1	G protein nucleolar 3 like
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cilium Motile Cilium Cell Projection	Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding RNA Binding Protein Binding GTP Binding
	Biological Process	Flagellated Sperm Motility Cilium Organization Sperm Capacitation Protein Localization To Cilium	Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Sumoylation Ribosome Biogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways		RHO GTPases Activate Rhotekin and Rhophilins	None
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 )	Prostate cancer ( 31562322 )
Novel Interactors		1 novel interactors: FAM162A	None recorded
Interacting Genes		50 interacting genes: AKAIN1 AKAP14 AKAP3 AKAP5 AKAP7 AP1M1 BTBD16 CDC37 CEP57L1 CKS1B CNST DBF4B ERCC3 FAM110A FAM153A FAM153B FAM161A FAM90A1 GNL3L GPKOW HNRNPUL1 KIAA0753 KIF9 LENG1 LMO4 LNX1 LNX2 NTAQ1 PICK1 PKP2 POLR3C PRDM6 PRKAA1 PSMA1 RHPN1 RTP5 SDCBP SERTAD1 SORBS3 SPA17 SPG21 SYTL4 TRIM3 TSGA10IP TSHZ3 TSNAXIP1 TULP3 UBE2W VPS33A XKR3	16 interacting genes: ADRB2 ALAS1 CTBP1 DYNLL1 GOLGA2 HMBOX1 HSF2BP KPNA1 LDOC1 LZTS2 MTUS2 PRKAR1B ROPN1 TERF1 TFIP11 TRIM54
Entrez ID		54763	54552
HPRD ID		15269	06514
Ensembl ID		ENSG00000065371	ENSG00000130119
Uniprot IDs		A0A140VKB2 Q9HAT0	Q05DU1 Q9NVN8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Kinase A Binding Protein Binding Protein Kinase A Regulatory Subunit Binding	Microtubule Double-stranded Telomeric DNA Binding Identical Protein Binding Microtubule Binding Telomere Maintenance Mitotic Spindle Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Telomere Organization Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of CAMP/PKA Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Reproductive Process Microtubule-based Process Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere DNA Metabolic Process Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Chromosome, Telomeric Region Microtubule Associated Complex Telomere-telomerase Complex Assembly Primary Ureteric Bud Growth Cytoplasm Microtubule Cytoskeleton Beta2-adrenergic Receptor Activity Establishment Of Localization In Cell Developmental Process 5-aminolevulinate Synthase Activity Response To Nickel Cation Cytoskeleton Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Spliceosomal Complex Disassembly Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Satellite Cell Activation Involved In Skeletal Muscle Regeneration Deoxyribonuclease Inhibitor Activity Centrosome Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity