SLC1A3 and SGK1

Number of citations of the paper that reports this interaction (PMID 12911626)
15

Data Source:
HPRD (in vitro)

		SLC1A3	SGK1
Gene Name		solute carrier family 1 (glial high affinity glutamate transporter), member 3	serum/glucocorticoid regulated kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cell Projection Neuronal Cell Body Fibril	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Glutamate Binding Sodium:dicarboxylate Symporter Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity
	Biological Process	Neurotransmitter Uptake Glutamate Biosynthetic Process Ion Transport Synaptic Transmission Sensory Perception Of Sound Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding Cranial Nerve Development Auditory Behavior Response To Drug Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transmembrane Transport D-aspartate Import L-glutamate Transmembrane Transport	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Neurotransmitter uptake and Metabolism In Glial Cells Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Transmission across Chemical Synapses	Ion channel transport Stimuli-sensing channels
Drugs		L-Glutamic Acid
Diseases
GWAS			Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		2 interactors: SGK1 ZDHHC17	31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C
Entrez ID		6507	6446
HPRD ID		02523	04264
Ensembl ID		ENSG00000079215	ENSG00000118515
Uniprot IDs		P43003 Q7Z5T0 Q8N169	E9PR89 O00141
PDB IDs			2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?		Renal Sodium Ion Absorption Renal Sodium Ion Transport Regulation Of Gastric Acid Secretion Renal Absorption Metal Ion Transport Lipoprotein Transport Magnesium Ion Transport Protein Palmitoylation Cation Transport Ion Transmembrane Transport Long-term Memory Positive Regulation Of Transporter Activity Transmembrane Transport Ion Transport	Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process
Tagcloud ?		acclimatization acclimatized altitude arteries bcl2 bioinformatic carotid cbf dot6 downregulated dysregulation fetus gestation homeobox intrauterine knotted lipoxygenase lth normoxic ovine pbx rpd3 rpd3c sox tod6 translated un upregulated utr	apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Difference) ?		acclimatization acclimatized altitude arteries bcl2 bioinformatic carotid cbf dot6 downregulated dysregulation fetus gestation homeobox intrauterine knotted lipoxygenase lth normoxic ovine pbx rpd3 rpd3c sox tod6 translated un upregulated utr	apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Intersection) ?