SLC1A3 and SGK1

Number of citations: 0 (PubMedID 12911626)
Data Source: HPRD (in vitro)

		SLC1A3	SGK1
Name		solute carrier family 1 member 3	serum/glucocorticoid regulated kinase 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Cell Periphery Membrane Protein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Acidic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Amino Acid Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Neurotransmitter Uptake Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Sodium Ion Homeostasis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding Neutral Amino Acid Transport L-glutamate Transmembrane Transport Cranial Nerve Development Auditory Behavior Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Potassium Ion Transmembrane Transport Import Into Cell L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC-mediated transport of amino acids	PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs		Glutamic acid	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases		Episodic ataxias	None
GWAS		Depression in smokers ( 30219690 ) Heel bone mineral density ( 28869591 30598549 ) Intraocular pressure ( 29617998 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Malaria ( 31844061 ) Serum alkaline phosphatase levels ( 33547301 )	Blond vs. brown/black hair color ( 30531825 ) Body mass index (smoking years interaction) ( 23192594 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465 ) Pelvic organ prolapse ( 26545240 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Refractive error ( 32231278 ) Schizophrenia (inflammation and infection response interaction) ( 25781172 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
Novel Interactors		1 novel interactors: RFX3	None recorded
Interacting Genes		6 interacting genes: BTN2A2 MGST3 SGK1 TMEM120B TMEM128 ZDHHC17	38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC
Entrez ID		6507	6446
HPRD ID		02523	04264
Ensembl ID		ENSG00000079215	ENSG00000118515
Uniprot IDs		A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169	B7Z325 E9PR89 O00141
PDB IDs		5LLM 5LLU 5LM4 5MJU 7NPW	2R5T 3HDM 3HDN 7PUE
GO Terms Enriched among Interactors		None	Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus