SLC1A3

Name	solute carrier family 1 member 3
Structure
Novel Interactors	1 novel interactors: RFX3
Interactors	6 interactors: BTN2A2 MGST3 SGK1 TMEM120B TMEM128 ZDHHC17
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Cell Periphery Membrane Protein Complex
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Acidic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Amino Acid Binding Metal Ion Binding
	Biological Process	Neurotransmitter Uptake Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Sodium Ion Homeostasis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding Neutral Amino Acid Transport L-glutamate Transmembrane Transport Cranial Nerve Development Auditory Behavior Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Potassium Ion Transmembrane Transport Import Into Cell L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC-mediated transport of amino acids
Drugs	Glutamic acid
Diseases	Episodic ataxias
GWAS	Depression in smokers ( 30219690 ) Heel bone mineral density ( 28869591 30598549 ) Intraocular pressure ( 29617998 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Malaria ( 31844061 ) Serum alkaline phosphatase levels ( 33547301 )
Entrez ID	6507
HPRD ID	02523
Ensembl ID	ENSG00000079215
Uniprot IDs	A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169
PDB IDs	5LLM 5LLU 5LM4 5MJU 7NPW