REEP1 and UNC93B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		REEP1	UNC93B1
Description		receptor accessory protein 1	unc-93B1 regulator of TLR signaling
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Mitochondrial Membrane Endoplasmic Reticulum Tubular Network	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle
	Molecular Function	Protein Binding Microtubule Binding Olfactory Receptor Binding	Protein Binding Toll-like Receptor Binding
	Biological Process	Protein Insertion Into Membrane Endoplasmic Reticulum Tubular Network Organization	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways		Expression and translocation of olfactory receptors	Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Atrial fibrillation ( 29892015 30061737) Facial emotion recognition (sad faces) ( 28608620) Night sleep phenotypes ( 27126917)	Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: CLDN10 CSRP1 STX7 TMEM100 TMEM42 TMEM97 UNC93B1	31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237
Entrez ID		65055	81622
HPRD ID		07810	12191
Ensembl ID		ENSG00000068615	ENSG00000110057
Uniprot IDs		A0A1C7CYY3 A0A2R8Y6K6 A0A8I5KRE1 A0A8I5QKJ2 Q9H902	Q9H1C4
PDB IDs			7C76 7CYN
Enriched GO Terms of Interacting Partners?			Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex
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