SLAMF1 and SH2D1B

Number of citations of the paper that reports this interaction (PubMedID 11689425)
51

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SLAMF1	SH2D1B
Description		signaling lymphocytic activation molecule family member 1	SH2 domain containing 1B
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Extracellular Exosome	Cytosol
	Molecular Function	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Negative Regulation Of Cytokine Production Leukocyte Chemotaxis Involved In Inflammatory Response Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Negative Regulation Of T Cell Cytokine Production Phagocytosis Immune Response Cell Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Chemotaxis Regulation Of Vesicle Fusion Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Activated T Cell Proliferation Innate Immune Response Leukocyte Activation Positive Regulation Of JNK Cascade Lymphocyte Activation Symbiont Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Cell Cytokine Production	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Memory decline ( 31985465) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)	Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)
Interacting Genes		6 interacting genes: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B	25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54
Entrez ID		6504	117157
HPRD ID		04603	12248
Ensembl ID		ENSG00000117090	ENSG00000198574
Uniprot IDs		B4E2E4 Q13291	O14796
PDB IDs		1D4T 1D4W 1I3Z 1KA6 1KA7 1M27	5KAZ
Enriched GO Terms of Interacting Partners?		Immune Effector Process Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Adaptive Immune Response Regulation Of Immune System Process Response To Stress Peptide Hormone Receptor Binding Immune System Process Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Immune Response Negative Regulation Of Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Innate Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell Activation Cell Activation Astrocyte Differentiation Negative Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Immune Response-activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Defense Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Projection Morphogenesis Neuron Projection Morphogenesis T Cell Costimulation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Innate Immune Response	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?