SLAMF1

Name	signaling lymphocytic activation molecule family member 1
Structure
Novel Interactors	1 novel interactors: PAX6
Interactors	6 interactors: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding
	Biological Process	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Negative Regulation Of Cytokine Production Leukocyte Chemotaxis Involved In Inflammatory Response Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Negative Regulation Of T Cell Cytokine Production Phagocytosis Immune Response Cell Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Chemotaxis Regulation Of Vesicle Fusion Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Activated T Cell Proliferation Innate Immune Response Leukocyte Activation Positive Regulation Of JNK Cascade Lymphocyte Activation Symbiont Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Cell Cytokine Production
GWAS	Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 23128233 ) Itch intensity from mosquito bite ( 28199695 ) Memory decline ( 31985465 ) Microalbuminuria ( 26631737 ) Multiple sclerosis ( 31604244 ) Schizophrenia (treatment resistant) ( 22479419 )
Entrez ID	6504
HPRD ID	04603
Ensembl ID	ENSG00000117090
Uniprot IDs	B4E2E4 Q13291
PDB IDs	1D4T 1D4W 1I3Z 1KA6 1KA7 1M27
GO Terms Enriched among Interactors ?	Immune Effector Process Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Adaptive Immune Response Regulation Of Immune System Process Response To Stress Peptide Hormone Receptor Binding Immune System Process Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Immune Response Negative Regulation Of Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Innate Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell Activation Cell Activation Astrocyte Differentiation Negative Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Immune Response-activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Defense Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Projection Morphogenesis Neuron Projection Morphogenesis T Cell Costimulation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Innate Immune Response