SLAMF1 and FGR

Number of citations: 0 (PubMedID 10229804)
Data Source: HPRD (in vitro, in vivo)

		SLAMF1	FGR
Name		signaling lymphocytic activation molecule family member 1	FGR proto-oncogene, Src family tyrosine kinase
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Aggresome Ruffle Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Negative Regulation Of Cytokine Production Leukocyte Chemotaxis Involved In Inflammatory Response Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Negative Regulation Of T Cell Cytokine Production Phagocytosis Immune Response Cell Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Chemotaxis Regulation Of Vesicle Fusion Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Activated T Cell Proliferation Innate Immune Response Leukocyte Activation Positive Regulation Of JNK Cascade Lymphocyte Activation Symbiont Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Cell Cytokine Production	Positive Regulation Of Cytokine Production Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		None	FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		None	Dasatinib Fostamatinib Zanubrutinib
GWAS		Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 23128233 ) Itch intensity from mosquito bite ( 28199695 ) Memory decline ( 31985465 ) Microalbuminuria ( 26631737 ) Multiple sclerosis ( 31604244 ) Schizophrenia (treatment resistant) ( 22479419 )	Body mass index ( 28892062 ) Systolic blood pressure ( 30224653 )
Novel Interactors		1 novel interactors: PAX6	None recorded
Interacting Genes		6 interacting genes: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B	30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		6504	2268
HPRD ID		04603	01288
Ensembl ID		ENSG00000117090	ENSG00000000938
Uniprot IDs		B4E2E4 Q13291	P09769 P78453
PDB IDs		1D4T 1D4W 1I3Z 1KA6 1KA7 1M27	7JT9 7UY0 7UY3
GO Terms Enriched among Interactors		Immune Effector Process Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Adaptive Immune Response Regulation Of Immune System Process Response To Stress Peptide Hormone Receptor Binding Immune System Process Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Immune Response Negative Regulation Of Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Innate Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell Activation Cell Activation Astrocyte Differentiation Negative Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Immune Response-activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Defense Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Projection Morphogenesis Neuron Projection Morphogenesis T Cell Costimulation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Innate Immune Response	Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death SH2 Domain Binding Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process ERBB2 Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Immune System Process Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Activity Negative Regulation Of Apoptotic Process