FLT3 and FMO1

		FLT3	FMO1
Description		fms related receptor tyrosine kinase 3	flavin containing dimethylaniline monoxygenase 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Endosome Membrane Membrane Protein-containing Complex Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Nuclear Glucocorticoid Receptor Binding Protein-containing Complex Binding Phosphatidylinositol 3-kinase Activator Activity	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Oxidoreductase Activity Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Lymphocyte Proliferation Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation Liver Regeneration	Sulfur Amino Acid Catabolic Process Organic Acid Metabolic Process Xenobiotic Metabolic Process Toxin Metabolic Process Response To Lipopolysaccharide Taurine Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Energy Homeostasis
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants	Degradation of cysteine and homocysteine FMO oxidises nucleophiles
Drugs		Sorafenib Sunitinib XL999 Tandutinib Linifanib Lestaurtinib Midostaurin Ponatinib Nintedanib Pacritinib Tivozanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases		Acute myeloid leukemia (AML)
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 27863252 32888494) White blood cell count (monocyte) ( 28158719)	Metabolite levels ( 23823483) Sudden cardiac arrest ( 21658281) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		18 interacting genes: CBL CBLB CTNNB1 ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6	7 interacting genes: CREB3 GRINA LEPROTL1 REEP4 SLC10A6 SLC71A2 TLN1
Entrez ID		2322	2326
HPRD ID		00635	00631
Ensembl ID		ENSG00000122025	ENSG00000010932
Uniprot IDs		P36888	B2RCG5 Q01740
PDB IDs		1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR 7QDP 7ZV9 8XB1
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Lymphocyte Activation Ephrin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Activation ERBB Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Cellular Response To Growth Factor Stimulus SH3 Domain Binding Response To Growth Factor Negative Regulation Of Leukocyte Activation Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Cell Activation Immune System Process Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Neutrophil Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Neutrophil Activation T Cell Receptor Signaling Pathway T Cell Costimulation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion	Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Membrane Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
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