VPS28 and ASF1A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		VPS28	ASF1A
Description		VPS28 subunit of ESCRT-I	anti-silencing function 1A histone chaperone
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GO Annotations	Cellular Component	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex Site Of Double-strand Break
	Molecular Function	Protein Binding Ubiquitin Binding Protein-containing Complex Binding	Chromatin Binding Protein Binding Histone Binding Histone Chaperone Activity
	Biological Process	Protein Transport Macroautophagy Negative Regulation Of Protein Ubiquitination Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Membrane Fission Positive Regulation Of Ubiquitin-dependent Endocytosis	Double-strand Break Repair Via Homologous Recombination Osteoblast Differentiation DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response Replication Fork Processing Muscle Cell Differentiation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988)	Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) QT interval ( 19305408)
Interacting Genes		48 interacting genes: ABI2 AKTIP ASF1A BEX2 BLZF1 CARD9 CBX5 CCDC146 CDK18 CEP57L1 CFTR COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SNCA SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52	32 interacting genes: ASF1B CHAF1A CHAF1B CHEK2 H3-3A H3-4 H3C3 H3C6 H4C1 H4C11 H4C12 H4C13 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HTATIP2 MCM2 PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17
Entrez ID		51160	25842
HPRD ID		11675	16459
Ensembl ID		ENSG00000160948	ENSG00000111875
Uniprot IDs		A0A0S2Z5H5 Q548N1 Q9UK41	Q9Y294
PDB IDs		6VME	1TEY 2I32 2IIJ 2IO5 3AAD 5C3I 6F0F 6F0G 6F0H 6ZUF 7LNY 7LO0 7V6Q 8BV1 8CJ1 8CJ2 8CJ3 8Z50
Enriched GO Terms of Interacting Partners?		Viral Budding Via Host ESCRT Complex Viral Budding ESCRT I Complex Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Membrane Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagy Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Protein Localization To Vacuole Protein Binding Vacuolar Transport Endosomal Transport Membrane Fission Multivesicular Body Sorting Pathway Cytoplasm Identical Protein Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization To Vacuole Nucleus Viral Process Calcium-dependent Protein Binding Microtubule Binding Positive Regulation Of Exocytosis AMP-activated Protein Kinase Activity Regulation Of Extracellular Exosome Assembly Protein Transport Vesicle Organization Protein Kinase Inhibitor Activity Protein Targeting Regulation Of Protein Modification Process Nucleotide-activated Protein Kinase Complex SMN Complex Protein Targeting To Vacuole Protein-containing Complex Binding Gemini Of Cajal Bodies Positive Regulation Of Actin Nucleation Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Protein Tag Activity Organelle Assembly Establishment Of Localization In Cell Intracellular Protein Localization SMN-Sm Protein Complex	Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Structural Constituent Of Chromatin Nucleosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Chromatin Organization Telomere Organization Chromatin Remodeling Chromosome, Telomeric Region Protein Localization To Chromatin Protein Heterodimerization Activity Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Protein-containing Complex Assembly Protein-containing Complex Chromosome Organization Protein-containing Complex Organization Chromosome Regulation Of Myeloid Cell Differentiation Cellular Component Assembly Regulation Of Hemopoiesis Extracellular Exosome Protein Localization To Organelle Nucleoplasm Negative Regulation Of Cell Differentiation DNA Binding DNA Replication-dependent Chromatin Assembly Regulation Of Cell Development Negative Regulation Of Developmental Process Intracellular Protein Localization Extracellular Region Organelle Organization RNA Binding Regulation Of Cell Differentiation Nucleus Regulation Of Multicellular Organismal Development Regulation Of Immune System Process CAF-1 Complex Regulation Of Developmental Process Histone Binding Protein Phosphorylation Protein Binding DNA Damage Response Phosphorylation RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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