IL36RN and SSBP2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		IL36RN	SSBP2
Description		interleukin 36 receptor antagonist	single stranded DNA binding protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding	DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Antifungal Humoral Response Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-36 pathway
Drugs
Diseases
GWAS		Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)	Adult body size ( 32376654) Anorexia nervosa ( 21079607) Bipolar disorder ( 31043756 33263727 34002096) Glioblastoma ( 22472174) HDL cholesterol levels in HIV infection ( 33109212) Plateletcrit ( 32888494)
Interacting Genes		18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B	7 interacting genes: CDK6 EWSR1 IL36RN LDB1 LDB2 PIN1 TOM1
Entrez ID		26525	23635
HPRD ID		16112	09577
Ensembl ID		ENSG00000136695	ENSG00000145687
Uniprot IDs		Q9UBH0	A0A087X159 P81877
PDB IDs		4P0J 4P0K 4P0L	6IWV 6TYD 8HIB
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding	LIM Domain Binding Transcription Coregulator Activity Regulation Of Metabolic Process Epithelial Structure Maintenance Negative Regulation Of Metabolic Process Regulation Of Erythrocyte Differentiation Cyclin D2-CDK6 Complex Cis-trans Isomerase Activity Cell Leading Edge Hair Follicle Development Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Establishment Of Protein Localization To Mitochondrion Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Somatic Stem Cell Population Maintenance Hair Cycle Process Myosin VI Binding Negative Regulation Of Biosynthetic Process
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