IL36RN and AP3M1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL36RN	AP3M1
Description		interleukin 36 receptor antagonist	adaptor related protein complex 3 subunit mu 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm Lysosome Lysosomal Membrane Early Endosome Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Recycling Endosome Axon Cytoplasm
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Antifungal Humoral Response Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide	Protein Targeting To Lysosome Intracellular Protein Transport Endocytosis Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Postsynaptic Neurotransmitter Receptor Internalization Melanosome Assembly
Pathways		Interleukin-36 pathway	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)	Cardiac troponin-I levels ( 31014085) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B	14 interacting genes: AGTRAP AQP4 ARNT2 CRMP1 DVL3 IL36RN RUFY1 SIPA1L2 SLC12A4 SPAG16 TGOLN2 TRIM14 TRIM23 TRIM9
Entrez ID		26525	26985
HPRD ID		16112	16496
Ensembl ID		ENSG00000136695	ENSG00000185009
Uniprot IDs		Q9UBH0	B4DRN6 Q9Y2T2
PDB IDs		4P0J 4P0K 4P0L	9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding	Cerebrospinal Fluid Circulation
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