IL36RN and SSBP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL36RN	SSBP3
Description		interleukin 36 receptor antagonist	single stranded DNA binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding	DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Antifungal Humoral Response Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide	Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Cell Population Proliferation Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Head Development Head Morphogenesis Protein-containing Complex Assembly Positive Regulation Of Anterior Head Development
Pathways		Interleukin-36 pathway
Drugs
Diseases
GWAS		Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)	Adult body size ( 32376654) Blood urea nitrogen levels ( 29403010 31152163) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Food allergy ( 25710614) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menarche (age at onset) ( 27182965) Monocyte count ( 32888494) P wave duration ( 28794112) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Refractive error ( 32231278) Serum bilirubin levels in metabolic syndrome ( 30621171) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549 32154731)
Interacting Genes		18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B	20 interacting genes: ANKEF1 APP ARNT2 BLK CLK1 DTNB EWSR1 HCLS1 IL36RN LDB1 LDB2 NXT2 PIN1 RFC1 SIVA1 SS18L1 SUPT5H TBC1D23 YES1 ZNF226
Entrez ID		26525	23648
HPRD ID		16112	09578
Ensembl ID		ENSG00000136695	ENSG00000157216
Uniprot IDs		Q9UBH0	Q9BWW4 Q9NW25
PDB IDs		4P0J 4P0K 4P0L
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process LIM Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Enzyme Binding Negative Regulation Of Transcription By RNA Polymerase II Antifungal Humoral Response Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Tyrosine Kinase Activity Transcription Coregulator Activity Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Nucleus Epithelial Structure Maintenance Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Dendrite Development Cis-trans Isomerase Activity Hair Follicle Development CD27 Receptor Binding Regulation Of Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Defense Response To Fungus Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Fungus Lipoprotein Particle
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