WNT7B and GPC3

Number of citations of the paper that reports this interaction (PMID 16227623)
18

Data Source:
HPRD (in vivo)

		WNT7B	GPC3
Gene Name		wingless-type MMTV integration site family, member 7B	glypican 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane	Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Frizzled Binding	Protein Binding Heparan Sulfate Proteoglycan Binding Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	In Utero Embryonic Development Metanephros Morphogenesis Activation Of JUN Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Neuron Differentiation Lung Development Oxygen Homeostasis Regulation Of Cell Projection Size Odontogenesis Of Dentin-containing Tooth Homeostatic Process Cellular Metabolic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of JNK Cascade Fibroblast Proliferation Embryonic Organ Development Neuron Projection Morphogenesis Synapse Organization Smooth Muscle Cell Differentiation Response To Glucocorticoid Anatomical Structure Regression Canonical Wnt Signaling Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development Apoptotic Process Involved In Patterning Of Blood Vessels	Retinoid Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Body Morphogenesis Negative Regulation Of Peptidase Activity Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Small Molecule Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Coronary Vasculature Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)
Protein-Protein Interactions		5 interactors: CASK CUL3 GPC3 PORCN TCEB1	4 interactors: FGF2 IGF2 WNT3A WNT7B
Entrez ID		7477	2719
HPRD ID		03573	02074
Ensembl ID		ENSG00000188064	ENSG00000147257
Uniprot IDs		A8K0G1 P56706	B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Trophectodermal Cellular Morphogenesis Negative Regulation Of Wnt Signaling Pathway Protein Metabolic Process Mesonephric Duct Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Wnt Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Wnt Signaling Pathway Mesonephric Duct Development Nephric Duct Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Proliferation Cell Proliferation Involved In Metanephros Development Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Regulation Of Protein Catabolic Process Embryonic Cleavage Positive Regulation Of Calcium Ion Import Stress Fiber Assembly Cell Proliferation Involved In Kidney Development Coronary Vasculature Development Positive Regulation Of Chromosome Segregation Glycoprotein Metabolic Process Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal Cell Proliferation Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter COPII Vesicle Coating Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Keratinocyte Proliferation COPII-coated Vesicle Budding Regulation Of Calcium Ion Import Negative Regulation Of Rho Protein Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Trophectodermal Cell Differentiation Mitotic Metaphase Plate Congression Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA-templated Transcription, Elongation Vesicle Targeting, To, From Or Within Golgi Protein Catabolic Process	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cell Fate Specification Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Fate Commitment Organ Morphogenesis Regulation Of Cell Fate Specification Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Muscle Cell Differentiation Regulation Of Cell Fate Commitment Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Epithelial Tube Morphogenesis Positive Regulation Of Receptor Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Tube Morphogenesis Positive Regulation Of MAPK Cascade Muscle Structure Development Regulation Of Cardiac Muscle Tissue Development Morphogenesis Of An Epithelium Cellular Response To Organic Substance Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Regulation Of Cellular Protein Metabolic Process Cellular Response To Retinoic Acid Skeletal System Development Wound Healing Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Embryonic Morphogenesis Stem Cell Proliferation Tissue Morphogenesis Canonical Wnt Signaling Pathway Renal Tubule Development Response To Wounding Tube Development Regulation Of Catalytic Activity Kidney Morphogenesis
Tagcloud ?		acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b	adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms
Tagcloud (Difference) ?		acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b	adulthood af amniotic band characterizing cloned declines decreasing developmental dramatically glypican immunoblot mannose midgestation mpr ontogeny parallels phosphomannan predispose preterm prominent pronounced quantitatively rodent rodents saturable see undergo wilms
Tagcloud (Intersection) ?