WNT7B and CUL3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		WNT7B	CUL3
Gene Name		wingless-type MMTV integration site family, member 7B	cullin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane	Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function	Frizzled Binding	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Metanephros Morphogenesis Activation Of JUN Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Neuron Differentiation Lung Development Oxygen Homeostasis Regulation Of Cell Projection Size Odontogenesis Of Dentin-containing Tooth Homeostatic Process Cellular Metabolic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of JNK Cascade Fibroblast Proliferation Embryonic Organ Development Neuron Projection Morphogenesis Synapse Organization Smooth Muscle Cell Differentiation Response To Glucocorticoid Anatomical Structure Regression Canonical Wnt Signaling Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development Apoptotic Process Involved In Patterning Of Blood Vessels	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829)
Protein-Protein Interactions		5 interactors: CASK CUL3 GPC3 PORCN TCEB1	54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4
Entrez ID		7477	8452
HPRD ID		03573	09123
Ensembl ID		ENSG00000188064	ENSG00000036257
Uniprot IDs		A8K0G1 P56706	B7Z600 Q13618
PDB IDs			4AP2 4APF 4EOZ 4HXI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Trophectodermal Cellular Morphogenesis Negative Regulation Of Wnt Signaling Pathway Protein Metabolic Process Mesonephric Duct Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Wnt Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Wnt Signaling Pathway Mesonephric Duct Development Nephric Duct Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Proliferation Cell Proliferation Involved In Metanephros Development Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Regulation Of Protein Catabolic Process Embryonic Cleavage Positive Regulation Of Calcium Ion Import Stress Fiber Assembly Cell Proliferation Involved In Kidney Development Coronary Vasculature Development Positive Regulation Of Chromosome Segregation Glycoprotein Metabolic Process Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal Cell Proliferation Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter COPII Vesicle Coating Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Keratinocyte Proliferation COPII-coated Vesicle Budding Regulation Of Calcium Ion Import Negative Regulation Of Rho Protein Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Trophectodermal Cell Differentiation Mitotic Metaphase Plate Congression Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA-templated Transcription, Elongation Vesicle Targeting, To, From Or Within Golgi Protein Catabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Difference) ?		acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic hinfp nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Intersection) ?