WNT4 and P2RX4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		WNT4	P2RX4
Gene Name		wingless-type MMTV integration site family, member 4	purinergic receptor P2X, ligand gated ion channel, 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface	Integral Component Of Nuclear Inner Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Neuronal Cell Body Terminal Bouton Dendritic Spine Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity Frizzled Binding Receptor Agonist Activity	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding ATP Binding Drug Binding Zinc Ion Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Androgen Biosynthetic Process Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Protein Palmitoylation Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway	Tissue Homeostasis Regulation Of Sodium Ion Transport Nitric Oxide Biosynthetic Process Transport Calcium Ion Transport Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Neuronal Action Potential Sensory Perception Of Pain Positive Regulation Of Prostaglandin Secretion Response To ATP Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Vasodilation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To ATP Apoptotic Signaling Pathway Cation Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Dupuytren's disease ( 21732829) Endometriosis ( 23104006 23472165 20601957) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: APP FZD6 P2RX4 PORCN SFRP1 SFRP2	6 interactors: CDH5 KRTAP5-9 MCM2 NOTCH2NL PIH1D3 WNT4
Entrez ID		54361	5025
HPRD ID		04601	09017
Ensembl ID		ENSG00000162552	ENSG00000135124
Uniprot IDs		B4DJF9 P56705	E7EPF7 F6RU17 Q5U089 Q99571
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Wnt Signaling Pathway Cellular Response To X-ray Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Involved In Somitogenesis Neural Tube Closure Neural Tube Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of JUN Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Developmental Growth Involved In Morphogenesis Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Cell Surface Receptor Signaling Pathway Tube Formation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Morphogenesis Of Embryonic Epithelium Regulation Of Organ Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Response To X-ray Negative Regulation Of JNK Cascade Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Stress-activated MAPK Cascade Developmental Growth Axis Elongation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Fat Cell Differentiation Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Ionizing Radiation Tube Morphogenesis Regulation Of Signal Transduction Signal Transduction Digestive Tract Morphogenesis Response To Radiation	Immature T Cell Proliferation In Thymus Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Male Gonad Development Positive Regulation Of Aldosterone Biosynthetic Process Female Sex Determination Regulation Of Testosterone Biosynthetic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Dermatome Development Thyroid-stimulating Hormone-secreting Cell Differentiation Renal Vesicle Induction Paramesonephric Duct Development Somatotropin Secreting Cell Differentiation Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Non-canonical Wnt Signaling Pathway Via MAPK Cascade Neuroendocrine Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Mammary Gland Branching Involved In Pregnancy Renal Vesicle Formation Blood Vessel Maturation Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process DNA Unwinding Involved In DNA Replication Positive Regulation Of Hormone Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Adenohypophysis Development Axonemal Dynein Complex Assembly Renal Vesicle Morphogenesis Androgen Biosynthetic Process Mesenchymal To Epithelial Transition Positive Regulation Of Meiotic Nuclear Division Metanephric Mesenchyme Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Metanephric Nephron Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Cellular Response To Epidermal Growth Factor Stimulus Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Collagen Metabolic Process DNA Strand Elongation Involved In DNA Replication
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?