WNT4

Gene Name		wingless-type MMTV integration site family, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	Transcription Corepressor Activity Frizzled Binding Receptor Agonist Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Androgen Biosynthetic Process Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Protein Palmitoylation Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Dupuytren's disease ( 21732829) Endometriosis ( 23104006 23472165 20601957) Obesity-related traits ( 23251661)
Protein-protein Interactions		6 interactors: APP FZD6 P2RX4 PORCN SFRP1 SFRP2
Entrez ID		54361
HPRD ID		04601
Ensembl ID		ENSG00000162552
Uniprot IDs		B4DJF9 P56705
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Wnt Signaling Pathway Cellular Response To X-ray Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Involved In Somitogenesis Neural Tube Closure Neural Tube Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of JUN Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Developmental Growth Involved In Morphogenesis Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Cell Surface Receptor Signaling Pathway Tube Formation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Morphogenesis Of Embryonic Epithelium Regulation Of Organ Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Response To X-ray Negative Regulation Of JNK Cascade Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Stress-activated MAPK Cascade Developmental Growth Axis Elongation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Fat Cell Differentiation Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Ionizing Radiation Tube Morphogenesis Regulation Of Signal Transduction Signal Transduction Digestive Tract Morphogenesis Response To Radiation
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a