NUCKS1 and GLP1R

Number of citations of the paper that reports this interaction (PubMedID 23864651)
34

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		NUCKS1	GLP1R
Description		nuclear casein kinase and cyclin dependent kinase substrate 1	glucagon like peptide 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding DNA-binding Transcription Factor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Intracellular Glucose Homeostasis Regulation Of DNA Replication DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Gene Conversion Interstrand Cross-link Repair Glucose Homeostasis Host-mediated Activation Of Viral Transcription Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA Strand Elongation Cellular Response To X-ray	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Free thyroxine concentration ( 30367059) HDL cholesterol levels ( 32203549) Menarche (age at onset) ( 25231870) Parkinson's disease ( 19915576 32201043 28892059 27182965 25064009 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Posterior thalamic nuclei volume ( 34006833) Prostate-specific antigen levels ( 25434496 23269536) Pubertal anthropometrics ( 23449627) QT interval ( 24952745) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Weight ( 28552196)	Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)
Interacting Genes		6 interacting genes: AK5 CEBPA DOCK9 GLP1R MDM2 RAD51AP1	112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99
Entrez ID		64710	2740
HPRD ID		11406	00677
Ensembl ID		ENSG00000069275	ENSG00000112164
Uniprot IDs		Q9H1E3	A0A142FHB8 P43220
PDB IDs			3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Response To Hormone Positive Regulation Of Proteasomal Protein Catabolic Process Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Response To Ionizing Radiation Cellular Response To Actinomycin D Centriolar Satellite D-loop DNA Binding Positive Regulation Of Reciprocal Meiotic Recombination DADP Biosynthetic Process Response To Nutrient Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Psychosocial Stress Cellular Response To Peptide Hormone Stimulus NEDD8 Ligase Activity Response To Actinomycin D Cellular Response To Radiation Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission DNA Secondary Structure Binding ADP Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Heart Contraction Receptor Serine/threonine Kinase Binding Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Response To Phenylpropanoid Protein Domain Specific Binding Fat Cell Proliferation Post-translational Protein Targeting To Membrane, Translocation	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration
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