IL1RL1

Gene Name		interleukin 1 receptor-like 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Receptor Signaling Protein Activity Protein Binding
	Biological Process	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-5 Production Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine Secretion
Pathways
Drugs
Diseases
GWAS		Asthma ( 23028483 21804549) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Eosinophil counts ( 19198610) Inflammatory bowel disease ( 23128233)
Protein-protein Interactions		6 interactors: APP CLEC7A IL33 MYD88 TIRAP TMED1
Entrez ID		9173
HPRD ID		03123
Ensembl ID		ENSG00000115602
Uniprot IDs		B4E0I3 Q01638
PDB IDs		4KC3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-6 Production 3'-UTR-mediated MRNA Stabilization Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Positive Regulation Of Innate Immune Response MRNA Stabilization Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Protein Metabolic Process Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Signal Transduction Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Posttranscriptional Regulation Of Gene Expression Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Toll-like Receptor 4 Signaling Pathway Signaling Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Negative Regulation Of Immunoglobulin Secretion TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway
Tagcloud ?		acetylated basophilic basophils chip clarify coexpression dendritic emsa encodes eosinophils gata gata1 gata2 introduced killer ku812 lad2 lineages mast modulator motifs possess repressed sirna sirnas st2 start th2 transactivated