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IL1RL1
Description
interleukin 1 receptor like 1
Image
GO Annotations
Cellular Component
Extracellular Region
Cytosol
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
Interleukin-33 Binding
Interleukin-33 Receptor Activity
Cytokine Receptor Activity
Interleukin-1 Receptor Activity
Protein Binding
Hydrolase Activity
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Biological Process
Negative Regulation Of T-helper 1 Type Immune Response
Inflammatory Response
Immune Response
Signal Transduction
Response To Wounding
Macrophage Differentiation
Negative Regulation Of Type II Interferon Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-5 Production
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Macrophage Activation
Positive Regulation Of Inflammatory Response
Pathways
PIP3 activates AKT signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling
Drugs
Diseases
GWAS
Adult asthma (
30578877
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Allergic rhinitis (
30013184
31361310
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
27182965
30929738
29273806
26620591
31361310
31619474
34103634
21804549
23028483
32296059
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
30929738
29273806
31036433
)
Asthma (moderate or severe) (
30552067
)
Asthma (time to onset) (
27130862
)
Asthma and hay fever (
24388013
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
23042114
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Celiac disease (
18311140
20190752
)
Childhood asthma with severe exacerbations (
33328473
)
Crohn's disease (
21102463
28067908
)
Delirium (
29631748
)
Eosinophil count (
29403010
32888494
19198610
)
Eosinophil percentage of white cells (
32888494
)
FEV1 (
30804560
)
Inflammatory bowel disease (
28067908
23128233
)
Lung function (FEV1/FVC) (
30804560
)
Nasal polyps (
30643255
)
Neutrophil percentage of white cells (
32888494
)
Primary biliary cholangitis (
26394269
)
Self-reported allergy (
23817569
)
Serum protein levels (sST2) (
23999434
)
Waist circumference (
23966867
)
Novel Interacting Genes
2 novel interacting genes:
HYOU1
TUBA4A
Interacting Genes
18 interacting genes:
APP
ASGR2
CLEC12B
CLEC2D
CLEC7A
CREB3L1
GPR152
GPR42
HRAS
IL33
MCFD2
MYD88
SIGLEC12
SLC38A1
TIRAP
TMED1
TSPAN18
YIPF6
Entrez ID
9173
HPRD ID
03123
Ensembl ID
ENSG00000115602
Uniprot IDs
Q01638
PDB IDs
4KC3
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Chemokine Production
Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Regulation Of Interleukin-6 Production
Regulation Of Tumor Necrosis Factor Production
Carbohydrate Binding
Vesicle-mediated Transport
Defense Response To Protozoan
Positive Regulation Of JNK Cascade
Response To Protozoan
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Leukocyte Activation Involved In Inflammatory Response
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Type II Interferon Production
Response To Molecule Of Fungal Origin
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Defense Response To Other Organism
Positive Regulation Of Cytokine Production
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of JNK Cascade
Positive Regulation Of Interleukin-23 Production
Immune Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-8 Production
Plasma Membrane
Regulation Of Interleukin-23 Production
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Cell Activation
Positive Regulation Of Interleukin-1 Production
Defense Response
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Type II Interferon Production
Immune Response-regulating Signaling Pathway
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Regulation Of Leukocyte Migration
Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Innate Immune Response
Response To Yeast
Positive Regulation Of MAPK Cascade
Positive Regulation Of Defense Response
Regulation Of Interleukin-8 Production
Defense Response To Symbiont
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Response To Endoplasmic Reticulum Stress
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