IL1RL1 and GPR42

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL1RL1	GPR42
Description		interleukin 1 receptor like 1	G protein-coupled receptor 42
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane
	Molecular Function	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Signal Transduction Response To Wounding Macrophage Differentiation Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 27182965 30929738 29273806 26620591 31361310 31619474 34103634 21804549 23028483 32296059 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 29273806 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 23042114) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 18311140 20190752) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Eosinophil count ( 29403010 32888494 19198610) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6	110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		9173	2866
HPRD ID		03123	16033
Ensembl ID		ENSG00000115602	ENSG00000126251
Uniprot IDs		Q01638	A0A0K0PUY3 O15529
PDB IDs		4KC3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Vesicle-mediated Transport Defense Response To Protozoan Positive Regulation Of JNK Cascade Response To Protozoan Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Response To Molecule Of Fungal Origin Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Cytokine Production Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of JNK Cascade Positive Regulation Of Interleukin-23 Production Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Plasma Membrane Regulation Of Interleukin-23 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Interleukin-1 Production Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Immune Response-regulating Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Leukocyte Migration Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Response To Yeast Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Regulation Of Interleukin-8 Production Defense Response To Symbiont MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress	Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion
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