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IL1RL1 and TMED1
Number of citations of the paper that reports this interaction (PMID
8621446
)
12
Data Source:
HPRD
(in vivo)
IL1RL1
TMED1
Gene Name
interleukin 1 receptor-like 1
transmembrane emp24 protein transport domain containing 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
External Side Of Plasma Membrane
Integral Component Of Membrane
Extracellular Matrix
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Plasma Membrane
Integral Component Of Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Molecular Function
Interleukin-33 Binding
Interleukin-33 Receptor Activity
Cytokine Receptor Activity
Interleukin-1 Receptor Activity
Receptor Signaling Protein Activity
Protein Binding
Receptor Binding
Protein Binding
Biological Process
Negative Regulation Of T-helper 1 Type Immune Response
Immune Response
Signal Transduction
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-5 Production
Intracellular Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Macrophage Activation
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Inflammatory Response
Positive Regulation Of Chemokine Secretion
Signal Transduction
Cell-cell Signaling
Protein Transport
Pathways
Drugs
Diseases
GWAS
Asthma (
23028483
21804549
)
Atopic dermatitis (
23042114
)
Celiac disease (
20190752
18311140
)
Crohn's disease (
21102463
)
Eosinophil counts (
19198610
)
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
6 interactors:
APP
CLEC7A
IL33
MYD88
TIRAP
TMED1
3 interactors:
IL1RL1
SEC23B
SMAD3
Entrez ID
9173
11018
HPRD ID
03123
05653
Ensembl ID
ENSG00000115602
Uniprot IDs
B4E0I3
Q01638
Q13445
PDB IDs
4KC3
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Chemokine Production
Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Regulation Of Interleukin-6 Production
3'-UTR-mediated MRNA Stabilization
Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Immune Response
Positive Regulation Of Innate Immune Response
MRNA Stabilization
Negative Regulation Of Growth Of Symbiont In Host
Innate Immune Response
Regulation Of Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Immune System Process
Positive Regulation Of Cell Activation
Positive Regulation Of Cytokine Production
Regulation Of MRNA Stability
Regulation Of RNA Stability
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of Cytokine Biosynthetic Process
Signal Transduction
Regulation Of Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Posttranscriptional Regulation Of Gene Expression
Defense Response
Immune Response-regulating Signaling Pathway
Regulation Of Cell Activation
Toll-like Receptor 4 Signaling Pathway
Signaling
Cell Communication
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cytokine Production
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Negative Regulation Of Immunoglobulin Secretion
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta3 Production
Evasion Or Tolerance Of Host Defenses By Virus
Regulation Of Inflammatory Response
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Protein Transport
Positive Regulation Of Cytokine Production
Primary MiRNA Processing
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
SMAD Protein Complex Assembly
Negative Regulation Of Osteoblast Proliferation
Negative Regulation Of T-helper 1 Type Immune Response
Positive Regulation Of Chemokine Secretion
Transdifferentiation
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Catenin Import Into Nucleus
Positive Regulation Of Alkaline Phosphatase Activity
Positive Regulation Of Macrophage Activation
Regulation Of Cytokine Production
Paraxial Mesoderm Morphogenesis
Nodal Signaling Pathway
Regulation Of Protein Transport
Positive Regulation Of Interleukin-5 Production
Positive Regulation Of Transforming Growth Factor Beta Production
Regulation Of Establishment Of Protein Localization
Regulation Of Osteoblast Proliferation
Embryonic Foregut Morphogenesis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Adherens Junction Organization
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Foregut Morphogenesis
Modulation By Virus Of Host Morphology Or Physiology
Paraxial Mesoderm Development
Regulation Of Catenin Import Into Nucleus
Positive Regulation Of Transport
Thyroid Gland Development
Osteoblast Development
Positive Regulation Of Interleukin-1 Beta Production
Regulation Of Macrophage Activation
Regulation Of Interleukin-5 Production
Regulation Of Protein Localization
Positive Regulation Of Chondrocyte Differentiation
Pericardium Development
Positive Regulation Of Phosphatase Activity
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Interleukin-1 Production
Signal Transduction Involved In Regulation Of Gene Expression
Activin Receptor Signaling Pathway
Tagcloud
?
acetylated
basophilic
basophils
chip
clarify
coexpression
dendritic
emsa
encodes
eosinophils
gata
gata1
gata2
introduced
killer
ku812
lad2
lineages
mast
modulator
motifs
possess
repressed
sirna
sirnas
st2
start
th2
transactivated
Tagcloud (Difference)
?
acetylated
basophilic
basophils
chip
clarify
coexpression
dendritic
emsa
encodes
eosinophils
gata
gata1
gata2
introduced
killer
ku812
lad2
lineages
mast
modulator
motifs
possess
repressed
sirna
sirnas
st2
start
th2
transactivated
Tagcloud (Intersection)
?