PPP1R21 and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		PPP1R21	SH2D2A
Description		protein phosphatase 1 regulatory subunit 21	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Membrane Early Endosome Membrane	Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Intracellular MRNA Localization	Angiogenesis Signal Transduction Cell Differentiation T Cell Proliferation
Pathways			VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal cancer ( 30529582) Educational attainment ( 27046643) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint mobility (Beighton score) ( 27182965) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 29403010) Prudent dietary pattern ( 28644415) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)	Autoimmune thyroid disease ( 32581359) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Sjögren's syndrome ( 28076899)
Interacting Genes		6 interacting genes: CFTR FBXO7 MTNR1B SH2D2A SH3GL2 ZDHHC17	34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1
Entrez ID		129285	9047
HPRD ID		17294	05152
Ensembl ID		ENSG00000162869	ENSG00000027869
Uniprot IDs		Q6ZMI0	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		7ND2
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Membrane Regulation Of Cell Communication Clathrin-coated Endocytic Vesicle Membrane Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Developmental Process Regulation Of Intracellular Signal Transduction Synapse Regulation Of ERBB Signaling Pathway Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Anion Channel Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Blood-brain Barrier Permeability Glutamatergic Synapse Lewy Body Core Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Biological Quality Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction Regulation Of Neuronal Action Potential Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Neuron Apoptotic Process Photoreceptor Ribbon Synapse	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction ATP Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Nucleotide Binding Signal Transduction Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Signaling Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Developmental Process Negative Regulation Of Programmed Cell Death Receptor Complex Cell Differentiation ERBB2 Signaling Pathway Protein Autophosphorylation Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Phosphorylation Regulation Of Epithelial Cell Proliferation Protein Phosphatase Binding Negative Regulation Of Defense Response SH2 Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Inflammatory Response Growth Factor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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