PPP1R21

Description		protein phosphatase 1 regulatory subunit 21
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GO Annotations	Cellular Component	Endosome Early Endosome Membrane Early Endosome Membrane
	Molecular Function	RNA Binding MRNA Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Intracellular MRNA Localization
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal cancer ( 30529582) Educational attainment ( 27046643) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint mobility (Beighton score) ( 27182965) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 29403010) Prudent dietary pattern ( 28644415) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)
Novel Interacting Genes		1 novel interacting genes: RTN4
Interacting Genes		6 interacting genes: CFTR FBXO7 MTNR1B SH2D2A SH3GL2 ZDHHC17
Entrez ID		129285
HPRD ID		17294
Ensembl ID		ENSG00000162869
Uniprot IDs		Q6ZMI0
PDB IDs		7ND2
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Membrane Regulation Of Cell Communication Clathrin-coated Endocytic Vesicle Membrane Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Developmental Process Regulation Of Intracellular Signal Transduction Synapse Regulation Of ERBB Signaling Pathway Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Anion Channel Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Blood-brain Barrier Permeability Glutamatergic Synapse Lewy Body Core Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Biological Quality Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction Regulation Of Neuronal Action Potential Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Neuron Apoptotic Process Photoreceptor Ribbon Synapse
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