RHEX and SH3GL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHEX	SH3GL1
Description		regulator of hemoglobinization and erythroid cell expansion	SH3 domain containing GRB2 like 1, endophilin A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse
	Molecular Function	Erythropoietin Receptor Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding
	Biological Process	Cell Differentiation Cellular Response To Erythropoietin Erythropoietin-mediated Signaling Pathway Erythrocyte Maturation Positive Regulation Of Erythrocyte Differentiation	Endocytosis Signal Transduction Central Nervous System Development
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		7 interacting genes: GAD2 GET3 PBX3 RBFA SH3GL1 SH3GLB1 SNX1	35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ
Entrez ID		440712	6455
HPRD ID		17400	03462
Ensembl ID		ENSG00000263961	ENSG00000141985
Uniprot IDs		Q6ZWK4	Q6FGM0 Q99961
PDB IDs
Enriched GO Terms of Interacting Partners?		Posterior Compartment Specification Anterior Compartment Pattern Formation Lipid Binding Cadherin Binding Protein Localization To Vacuolar Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity GET Complex Compartment Pattern Specification Retromer, Tubulation Complex Leptin Receptor Binding 'de Novo' Post-translational Protein Folding Positive Regulation Of Membrane Tubulation Dorsal Spinal Cord Development Autophagic Cell Death Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Early Endosome Membrane Lamellipodium Morphogenesis Phosphatidylinositol 3-kinase Activator Activity Carbon-carbon Lyase Activity 'de Novo' Protein Folding	Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission
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