EEIG1 and SKAP2

Number of citations of the paper that reports this interaction (PubMedID 29568343)
46

Data Source:
BioGRID (protein complementation assay)

		EEIG1	SKAP2
Description		estrogen-induced osteoclastogenesis regulator 1	src kinase associated phosphoprotein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Membrane Raft	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of Osteoclast Differentiation	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation
Pathways			Signal regulatory protein family interactions
Drugs
Diseases
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Hip index ( 34021172) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)
Interacting Genes		9 interacting genes: BCAR1 CFTR CYSRT1 ENKD1 NEDD9 PFDN5 SH3GL1 SKAP1 SKAP2	20 interacting genes: APP BLK DNAJB6 EEIG1 FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID		399665	8935
HPRD ID		13262	05558
Ensembl ID		ENSG00000167106	ENSG00000005020
Uniprot IDs		Q5T9C2	B7Z5R3 O75563
PDB IDs			3OMH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Anchoring Junction Immunological Synapse Positive Regulation Of Immunological Synapse Formation Integrin-mediated Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly SH3 Domain Binding T Cell Receptor Signaling Pathway	Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Immune System Process Protein Phosphorylation Regulation Of Immune Response Phosphorylation Membrane Raft Protein Autophosphorylation Signaling Receptor Activator Activity Antigen Receptor-mediated Signaling Pathway Integrin-mediated Signaling Pathway Signal Transduction T Cell Costimulation Phosphotyrosine Residue Binding Negative Regulation Of Immune Response Ephrin Receptor Signaling Pathway ATP Binding Immune Effector Process Positive Regulation Of Intracellular Signal Transduction Cellular Developmental Process Negative Regulation Of Defense Response Regulation Of Transport Ephrin Receptor Binding Negative Regulation Of Inflammatory Response Nucleotide Binding Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process
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