SGCD and FLNC

Number of citations of the paper that reports this interaction (PubMedID 10629222)
54

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SGCD	FLNC
Description		sarcoglycan delta	filamin C
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcoplasmic Reticulum Sarcolemma	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge
	Molecular Function		Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Heart Process Muscle Organ Development Calcium-mediated Signaling Protein-containing Complex Localization Cardiac Muscle Tissue Development Cardiac Muscle Cell Development Calcium Ion Homeostasis Heart Contraction Cardiac Muscle Contraction Coronary Vasculature Morphogenesis Cardiac Muscle Cell Contraction	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Cell-extracellular matrix interactions
Drugs
Diseases		Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Age at first birth ( 34211149) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anthropometric traits ( 19260139) Daytime sleep phenotypes ( 27126917) Egg allergy ( 25710614) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Evening vs. morning chronotype (sMEQ score) ( 32579418) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycemic traits (pleiotropy) ( 31021400) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HIV-1 viral setpoint ( 26039976) Mental health related quality of life ( 33578652) Multiple sclerosis (age of onset) ( 19010793) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Resting-state electroencephalogram vigilance ( 29703947) Schizophrenia ( 33169155) Smoking initiation ( 33082346) Superior temporal sulcus banks volume ( 31530798) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		7 interacting genes: ADA CRYAA FLNC SERPINA3 SGCA SGCB SGCG	35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		6444	2318
HPRD ID		03246	00018
Ensembl ID		ENSG00000170624	ENSG00000128591
Uniprot IDs		Q92629	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
Enriched GO Terms of Interacting Partners?		Sarcoglycan Complex Dystroglycan Complex Sarcolemma Muscle Organ Development Muscle Structure Development Dystrophin-associated Glycoprotein Complex Animal Organ Development System Process Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Muscle Cell Development Negative Regulation Of Mature B Cell Apoptotic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Hypoxanthine Metabolic Process Cytoplasmic Vesicle Lumen Adenosine Catabolic Process DAMP Catabolic Process Hypoxanthine Biosynthetic Process Cytoskeleton Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process AMP Catabolic Process Deoxyribonucleoside Catabolic Process AMP Salvage Glucose Import In Response To Insulin Stimulus Allantoin Metabolic Process Deaminase Activity Mucosa-associated Lymphoid Tissue Development Positive Regulation Of T Cell Differentiation In Thymus Peyer's Patch Development Regulation Of Mucus Secretion Regulation Of Germinal Center Formation Muscle Contraction Purine Nucleoside Catabolic Process Adenosine Deaminase Activity Lens Fiber Cell Morphogenesis Germinal Center B Cell Differentiation	Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication
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