SGCD and SGCB

Number of citations of the paper that reports this interaction (PubMedID 9864373)
68

Data Source:
HPRD (in vivo)

		SGCD	SGCB
Description		sarcoglycan delta	sarcoglycan beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcoplasmic Reticulum Sarcolemma	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma
	Molecular Function		Protein Binding
	Biological Process	Heart Process Muscle Organ Development Calcium-mediated Signaling Protein-containing Complex Localization Cardiac Muscle Tissue Development Cardiac Muscle Cell Development Calcium Ion Homeostasis Heart Contraction Cardiac Muscle Contraction Coronary Vasculature Morphogenesis Cardiac Muscle Cell Contraction	Muscle Organ Development Response To Glucose Gene Expression Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Muscle Cell Development Cardiac Muscle Cell Development Vascular Associated Smooth Muscle Cell Development
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F	Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Age at first birth ( 34211149) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anthropometric traits ( 19260139) Daytime sleep phenotypes ( 27126917) Egg allergy ( 25710614) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Evening vs. morning chronotype (sMEQ score) ( 32579418) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycemic traits (pleiotropy) ( 31021400) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HIV-1 viral setpoint ( 26039976) Mental health related quality of life ( 33578652) Multiple sclerosis (age of onset) ( 19010793) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Resting-state electroencephalogram vigilance ( 29703947) Schizophrenia ( 33169155) Smoking initiation ( 33082346) Superior temporal sulcus banks volume ( 31530798) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		7 interacting genes: ADA CRYAA FLNC SERPINA3 SGCA SGCB SGCG	22 interacting genes: ADAM33 ADRA1A APOL3 ATP1B4 CLEC7A CMTM5 EHHADH HTR2C LTB4R2 MAL MGST2 NINJ1 PTTG1IP SGCA SGCD SGCG SGCZ SLC52A1 SMIM3 TMEM11 TNF TRIM63
Entrez ID		6444	6443
HPRD ID		03246	02942
Ensembl ID		ENSG00000170624	ENSG00000163069
Uniprot IDs		Q92629	Q16585 Q5U0N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Sarcoglycan Complex Dystroglycan Complex Sarcolemma Muscle Organ Development Muscle Structure Development Dystrophin-associated Glycoprotein Complex Animal Organ Development System Process Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Muscle Cell Development Negative Regulation Of Mature B Cell Apoptotic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Hypoxanthine Metabolic Process Cytoplasmic Vesicle Lumen Adenosine Catabolic Process DAMP Catabolic Process Hypoxanthine Biosynthetic Process Cytoskeleton Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process AMP Catabolic Process Deoxyribonucleoside Catabolic Process AMP Salvage Glucose Import In Response To Insulin Stimulus Allantoin Metabolic Process Deaminase Activity Mucosa-associated Lymphoid Tissue Development Positive Regulation Of T Cell Differentiation In Thymus Peyer's Patch Development Regulation Of Mucus Secretion Regulation Of Germinal Center Formation Muscle Contraction Purine Nucleoside Catabolic Process Adenosine Deaminase Activity Lens Fiber Cell Morphogenesis Germinal Center B Cell Differentiation	Sarcoglycan Complex Dystroglycan Complex Membrane Heart Contraction Muscle Contraction Heart Process Sarcolemma Muscle System Process Circulatory System Process Plasma Membrane Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Action Potential Cardiac Muscle Tissue Development Negative Regulation Of Heart Rate Dystrophin-associated Glycoprotein Complex Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Heart Contraction Negative Regulation Of Blood Circulation Muscle Organ Development Negative Regulation Of Myoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Ferroptosis Muscle Structure Development Muscle Tissue Development Negative Regulation Of Bile Acid Secretion Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Metabolic Process Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Inflammatory Response Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure System Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
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