SGCD and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SGCD	SERPINA3
Description		sarcoglycan delta	serpin family A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcoplasmic Reticulum Sarcolemma	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function		DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Heart Process Muscle Organ Development Calcium-mediated Signaling Protein-containing Complex Localization Cardiac Muscle Tissue Development Cardiac Muscle Cell Development Calcium Ion Homeostasis Heart Contraction Cardiac Muscle Contraction Coronary Vasculature Morphogenesis Cardiac Muscle Cell Contraction	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Platelet degranulation Neutrophil degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Age at first birth ( 34211149) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anthropometric traits ( 19260139) Daytime sleep phenotypes ( 27126917) Egg allergy ( 25710614) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Evening vs. morning chronotype (sMEQ score) ( 32579418) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycemic traits (pleiotropy) ( 31021400) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HIV-1 viral setpoint ( 26039976) Mental health related quality of life ( 33578652) Multiple sclerosis (age of onset) ( 19010793) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Resting-state electroencephalogram vigilance ( 29703947) Schizophrenia ( 33169155) Smoking initiation ( 33082346) Superior temporal sulcus banks volume ( 31530798) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)
Interacting Genes		7 interacting genes: ADA CRYAA FLNC SERPINA3 SGCA SGCB SGCG	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		6444	12
HPRD ID		03246	00120
Ensembl ID		ENSG00000170624	ENSG00000196136
Uniprot IDs		Q92629	P01011
PDB IDs			1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
Enriched GO Terms of Interacting Partners?		Sarcoglycan Complex Dystroglycan Complex Sarcolemma Muscle Organ Development Muscle Structure Development Dystrophin-associated Glycoprotein Complex Animal Organ Development System Process Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Muscle Cell Development Negative Regulation Of Mature B Cell Apoptotic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Hypoxanthine Metabolic Process Cytoplasmic Vesicle Lumen Adenosine Catabolic Process DAMP Catabolic Process Hypoxanthine Biosynthetic Process Cytoskeleton Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process AMP Catabolic Process Deoxyribonucleoside Catabolic Process AMP Salvage Glucose Import In Response To Insulin Stimulus Allantoin Metabolic Process Deaminase Activity Mucosa-associated Lymphoid Tissue Development Positive Regulation Of T Cell Differentiation In Thymus Peyer's Patch Development Regulation Of Mucus Secretion Regulation Of Germinal Center Formation Muscle Contraction Purine Nucleoside Catabolic Process Adenosine Deaminase Activity Lens Fiber Cell Morphogenesis Germinal Center B Cell Differentiation	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath
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