HIST1H1D and IRAK4

Number of citations of the paper that reports this interaction (PMID 15927069)
0

Data Source:
BioGRID (enzymatic study)

		HIST1H1D	IRAK4
Gene Name		histone cluster 1, H1d	interleukin-1 receptor-associated kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nuclear Euchromatin	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Chromatin DNA Binding Poly(A) RNA Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning	Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation JNK Cascade Cytokine-mediated Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS		Height ( 19343178 18391950)	Immune reponse to smallpox (secreted TNF-alpha) ( 22610502)
Protein-Protein Interactions		7 interactors: CDK1 CDK2 CDK4 EP300 IRAK4 NSD1 PRKCA	18 interactors: ARNT EIF4EBP1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6
Entrez ID		3007	51135
HPRD ID		06764	06051
Ensembl ID		ENSG00000124575	ENSG00000198001
Uniprot IDs		P16402	B2RAP9 B4E359 Q69FE3 Q9NWZ3
PDB IDs			2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP
Enriched GO Terms of Interacting Partners?		Chromatin Organization Histone Modification Chromosome Organization Histone Phosphorylation Chromatin Modification Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cell Proliferation Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Cell Cycle Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Protein Metabolic Process Innate Immune Response Mitotic Nuclear Envelope Disassembly Phosphorylation Intracellular Signal Transduction Positive Regulation Of Metabolic Process Response To Stress Nuclear Envelope Disassembly Regulation Of Cellular Protein Metabolic Process Peptidyl-threonine Phosphorylation Peptidyl-amino Acid Modification Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Centrosome Cycle Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of DNA Replication Nuclear Envelope Organization Organ Regeneration	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleosome Assembly Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Chromatin Assembly Nucleosome Organization Toll-like Receptor 9 Signaling Pathway Response To Bacterium Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Cytokine Production DNA Packaging Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Nucleosome Positioning Response To Other Organism Immune Response-regulating Signaling Pathway Response To Biotic Stimulus DNA Conformation Change Positive Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Regulation Of Immune System Process Defense Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Protein Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Proliferation Response To Lipid
Tagcloud ?			curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Difference) ?			curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Intersection) ?