SRSF3 and CLK1

Number of citations of the paper that reports this interaction (PMID 12890497)
11

Data Source:
BioGRID (two hybrid)

		SRSF3	CLK1
Gene Name		serine/arginine-rich splicing factor 3	CDC-like kinase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	Cell Proliferation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs			Debromohymenialdisine ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP CHD1 CLK1 EXOSC6 GEMIN2 HNRNPK IL7R NXF1 PCBP1 PCBP2 PRPF38A RBM7 RBMY1A1 SCAF11 SREK1 SRPK1 SRPK2 SRSF2 TRA2B YWHAB YWHAG YWHAQ	20 interactors: BCLAF1 GOLM1 KRTAP10-7 LUC7L3 MBP NCOR1 PDE9A PIAS4 PPIG PRMT5 PRPF4 PTPN1 SAFB SRPK1 SRPK2 SRSF1 SRSF3 SRSF6 UBL5 YWHAG
Entrez ID		6428	1195
HPRD ID		04530	09058
Ensembl ID			ENSG00000013441
Uniprot IDs		B2R6F3 P84103	P49759
PDB IDs		2I2Y 2I38	1Z57 2VAG
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Spliceosomal Complex Assembly Regulation Of Mitochondrion Organization Immune Response Positive Regulation Of Viral Genome Replication Ribonucleoprotein Complex Biogenesis Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Intrinsic Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Viral Genome Replication Cellular Metabolic Process Nuclear Speck Organization Positive Regulation Of Intracellular Transport Immunoglobulin Production Cellular Process MRNA Export From Nucleus Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intracellular Transport Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Interleukin-7-mediated Signaling Pathway RNA Export From Nucleus Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Cell Death	RNA Splicing MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Spliceosomal Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecular Complex Assembly Nuclear Export MRNA Transport Nucleus Organization Positive Regulation Of Viral Genome Replication RNA Transport Transcription, DNA-templated RNA Localization RNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Viral Genome Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Speck Organization Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Response To DNA Damage Stimulus Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Cell Death Cellular Metabolic Process Regulation Of Viral Genome Replication
Tagcloud ?		1alpha activate alter atpase cadherin caffeine cardiac conferred depletion detailed digoxin g2 glycosides governing hela hypoxia isoform mesenchymal modulate modulated na p53alpha p53beta pumping repositioning snail splicing switch transition	10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq
Tagcloud (Difference) ?		1alpha activate alter atpase cadherin caffeine cardiac conferred depletion detailed digoxin g2 glycosides hela hypoxia isoform mesenchymal modulate modulated na p53alpha p53beta pumping repositioning snail splicing switch transition	10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq
Tagcloud (Intersection) ?		governing