SFRP1 and WNT2

Number of citations of the paper that reports this interaction (PMID 10347172)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		SFRP1	WNT2
Gene Name		secreted frizzled-related protein 1	wingless-type MMTV integration site family member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Plasma Membrane Extracellular Matrix
	Molecular Function	Cysteine-type Endopeptidase Activity G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Drug Binding Heparin Binding Wnt-protein Binding Identical Protein Binding Wnt-activated Receptor Activity	Frizzled Binding Cytokine Activity Protein Binding Receptor Agonist Activity
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Dorsal/ventral Axis Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Neural Crest Cell Fate Commitment Response To Organic Cyclic Compound Menstrual Cycle Phase Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Rac GTPase Activity Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Neuron Differentiation Lung Development Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Dupuytren's disease ( 21732829) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		6 interactors: FZD6 KIAA1522 PPP1CA WNT1 WNT2 WNT4	8 interactors: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A
Entrez ID		6422	7472
HPRD ID		09165	00999
Ensembl ID		ENSG00000104332	ENSG00000105989
Uniprot IDs		Q6ZSL4 Q8N474	A4D0V1 P09544
PDB IDs
Enriched GO Terms of Interacting Partners?		Tissue Morphogenesis Positive Regulation Of Embryonic Development Tube Development Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Receptor Activity Wnt Signaling Pathway Positive Regulation Of Dermatome Development Developmental Induction Regulation Of Wnt Signaling Pathway Epithelium Development Epithelial Tube Morphogenesis Tube Morphogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Morphogenesis Of An Epithelium Regulation Of Embryonic Development Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Tissue Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anatomical Structure Morphogenesis Organ Morphogenesis Non-canonical Wnt Signaling Pathway Cell Fate Commitment Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryo Development Negative Regulation Of Signaling Organ Development Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Epithelial To Mesenchymal Transition Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Embryonic Organ Development Ureteric Bud Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gland Development Muscle Structure Development Nephron Morphogenesis	Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Wnt Signaling Pathway Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Osteoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Acid Chemical Regulation Of Catenin Import Into Nucleus Regulation Of Organ Morphogenesis Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Axis Elongation Ossification Negative Regulation Of BMP Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuroblast Proliferation Organ Morphogenesis Cellular Response To Lipid Regulation Of BMP Signaling Pathway Somitogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Respiratory Burst After Phagocytosis Convergent Extension Involved In Somitogenesis Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Positive Regulation Of Mesodermal Cell Fate Specification Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Stem Cell Proliferation Negative Regulation Of Developmental Growth Cellular Response To Organonitrogen Compound Regulation Of Cell Morphogenesis Growth Somite Development Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Neural Precursor Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Cardiac Cell Fate Specification Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Tagcloud ?		aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		aberrant ag alterations array basel bead bench breast cancers cdh1 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?		dkk3