SFRP1 and WNT4

Number of citations of the paper that reports this interaction (PMID 11287180)
18

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		SFRP1	WNT4
Gene Name		secreted frizzled-related protein 1	wingless-type MMTV integration site family, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	Cysteine-type Endopeptidase Activity G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Drug Binding Heparin Binding Wnt-protein Binding Identical Protein Binding Wnt-activated Receptor Activity	Transcription Corepressor Activity Frizzled Binding Receptor Agonist Activity
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Dorsal/ventral Axis Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Neural Crest Cell Fate Commitment Response To Organic Cyclic Compound Menstrual Cycle Phase Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Rac GTPase Activity Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Androgen Biosynthetic Process Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Protein Palmitoylation Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Dupuytren's disease ( 21732829) Endometriosis ( 23104006 23472165 20601957) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: FZD6 KIAA1522 PPP1CA WNT1 WNT2 WNT4	6 interactors: APP FZD6 P2RX4 PORCN SFRP1 SFRP2
Entrez ID		6422	54361
HPRD ID		09165	04601
Ensembl ID		ENSG00000104332	ENSG00000162552
Uniprot IDs		Q6ZSL4 Q8N474	B4DJF9 P56705
PDB IDs
Enriched GO Terms of Interacting Partners?		Tissue Morphogenesis Positive Regulation Of Embryonic Development Tube Development Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Receptor Activity Wnt Signaling Pathway Positive Regulation Of Dermatome Development Developmental Induction Regulation Of Wnt Signaling Pathway Epithelium Development Epithelial Tube Morphogenesis Tube Morphogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Morphogenesis Of An Epithelium Regulation Of Embryonic Development Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Tissue Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anatomical Structure Morphogenesis Organ Morphogenesis Non-canonical Wnt Signaling Pathway Cell Fate Commitment Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryo Development Negative Regulation Of Signaling Organ Development Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Epithelial To Mesenchymal Transition Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Embryonic Organ Development Ureteric Bud Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gland Development Muscle Structure Development Nephron Morphogenesis	Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Wnt Signaling Pathway Cellular Response To X-ray Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Involved In Somitogenesis Neural Tube Closure Neural Tube Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of JUN Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Developmental Growth Involved In Morphogenesis Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Cell Surface Receptor Signaling Pathway Tube Formation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Morphogenesis Of Embryonic Epithelium Regulation Of Organ Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Response To X-ray Negative Regulation Of JNK Cascade Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Stress-activated MAPK Cascade Developmental Growth Axis Elongation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Fat Cell Differentiation Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Ionizing Radiation Tube Morphogenesis Regulation Of Signal Transduction Signal Transduction Digestive Tract Morphogenesis Response To Radiation
Tagcloud ?		aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		aberrant ag alterations array basel bead bench breast cancers cdh1 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?		dkk3