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SFRP1
Gene Name
secreted frizzled-related protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Proteinaceous Extracellular Matrix
Extracellular Space
Intracellular
Cytosol
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Extracellular Matrix
Extracellular Vesicular Exosome
Molecular Function
Cysteine-type Endopeptidase Activity
G-protein Coupled Receptor Activity
Frizzled Binding
Protein Binding
Drug Binding
Heparin Binding
Wnt-protein Binding
Identical Protein Binding
Wnt-activated Receptor Activity
Biological Process
Osteoblast Differentiation
Ureteric Bud Development
Neural Tube Closure
Positive Regulation Of Cell-matrix Adhesion
Hematopoietic Progenitor Cell Differentiation
Proteolysis
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Male Gonad Development
Female Gonad Development
Cellular Response To Starvation
Dorsal/ventral Axis Specification
Regulation Of Cell Cycle Process
Negative Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Neural Crest Cell Fate Commitment
Response To Organic Cyclic Compound
Menstrual Cycle Phase
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Ossification
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Osteoblast Proliferation
Somatic Stem Cell Maintenance
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of JUN Kinase Activity
Cellular Response To Fibroblast Growth Factor Stimulus
Stromal-epithelial Cell Signaling Involved In Prostate Gland Development
Negative Regulation Of B Cell Differentiation
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Osteoclast Differentiation
Regulation Of Angiogenesis
Positive Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Secretion
Negative Regulation Of Bone Remodeling
Negative Regulation Of Fibroblast Proliferation
Digestive Tract Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Canonical Wnt Signaling Pathway
Hematopoietic Stem Cell Differentiation
Bone Trabecula Formation
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Regulation Of Branching Involved In Prostate Gland Morphogenesis
Negative Regulation Of Androgen Receptor Signaling Pathway
Cellular Response To Vitamin D
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To X-ray
Cellular Response To Heparin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Wnt Signaling Pathway Involved In Somitogenesis
Convergent Extension Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation
Negative Regulation Of Fibroblast Apoptotic Process
Positive Regulation Of Fibroblast Apoptotic Process
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
negative regulation of TCF-dependent signaling by WNT ligand antagonists
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions
6 interactors:
FZD6
KIAA1522
PPP1CA
WNT1
WNT2
WNT4
Entrez ID
6422
HPRD ID
09165
Ensembl ID
ENSG00000104332
Uniprot IDs
Q6ZSL4
Q8N474
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tissue Morphogenesis
Positive Regulation Of Embryonic Development
Tube Development
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Receptor Activity
Wnt Signaling Pathway
Positive Regulation Of Dermatome Development
Developmental Induction
Regulation Of Wnt Signaling Pathway
Epithelium Development
Epithelial Tube Morphogenesis
Tube Morphogenesis
Canonical Wnt Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Morphogenesis Of An Epithelium
Regulation Of Embryonic Development
Regulation Of Receptor Activity
Positive Regulation Of Canonical Wnt Signaling Pathway
Tissue Development
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Organ Morphogenesis
Regulation Of Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Branching Morphogenesis Of An Epithelial Tube
Morphogenesis Of A Branching Epithelium
Morphogenesis Of A Branching Structure
Anatomical Structure Morphogenesis
Organ Morphogenesis
Non-canonical Wnt Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Embryo Development
Negative Regulation Of Signaling
Organ Development
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Epithelial To Mesenchymal Transition
Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Fibroblast Proliferation
T Cell Differentiation In Thymus
Embryonic Organ Development
Ureteric Bud Morphogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Gland Development
Muscle Structure Development
Nephron Morphogenesis
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