SFRP1 and FZD6

Number of citations of the paper that reports this interaction (PMID 10347172)
54

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SFRP1	FZD6
Gene Name		secreted frizzled-related protein 1	frizzled class receptor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Drug Binding Heparin Binding Wnt-protein Binding Identical Protein Binding Wnt-activated Receptor Activity	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Dorsal/ventral Axis Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Neural Crest Cell Fate Commitment Response To Organic Cyclic Compound Menstrual Cycle Phase Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Rac GTPase Activity Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development G-protein Coupled Receptor Signaling Pathway Platelet Activation Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: FZD6 KIAA1522 PPP1CA WNT1 WNT2 WNT4	2 interactors: SFRP1 WNT4
Entrez ID		6422	8323
HPRD ID		09165	04559
Ensembl ID		ENSG00000104332	ENSG00000164930
Uniprot IDs		Q6ZSL4 Q8N474	B4E236 O60353
PDB IDs
Enriched GO Terms of Interacting Partners?		Tissue Morphogenesis Positive Regulation Of Embryonic Development Tube Development Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Receptor Activity Wnt Signaling Pathway Positive Regulation Of Dermatome Development Developmental Induction Regulation Of Wnt Signaling Pathway Epithelium Development Epithelial Tube Morphogenesis Tube Morphogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Morphogenesis Of An Epithelium Regulation Of Embryonic Development Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Tissue Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anatomical Structure Morphogenesis Organ Morphogenesis Non-canonical Wnt Signaling Pathway Cell Fate Commitment Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryo Development Negative Regulation Of Signaling Organ Development Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Epithelial To Mesenchymal Transition Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Embryonic Organ Development Ureteric Bud Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gland Development Muscle Structure Development Nephron Morphogenesis	Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell-matrix Adhesion Epithelial To Mesenchymal Transition Regulation Of Cell Junction Assembly Regulation Of Stress Fiber Assembly Canonical Wnt Signaling Pathway Female Gonad Development Development Of Primary Female Sexual Characteristics Regulation Of Embryonic Development Mesenchymal Cell Development Ureteric Bud Development Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Canonical Wnt Signaling Pathway Mesonephros Development Regulation Of Osteoblast Differentiation Mesenchymal Cell Differentiation Cellular Response To Starvation Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Male Gonad Development Kidney Epithelium Development Gland Morphogenesis Tube Formation Morphogenesis Of Embryonic Epithelium Cellular Response To Nutrient Levels Response To Starvation Regulation Of Organ Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Male Sex Differentiation Response To Transforming Growth Factor Beta Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Migration Regulation Of Ossification Positive Regulation Of Cytoskeleton Organization Mesenchyme Development Immature T Cell Proliferation In Thymus Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testicular Blood Vessel Morphogenesis
Tagcloud ?		aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	10b 3a 5b 7a 9b affinities argues comprise dividing employ ethylmaleimide frap frizzled hardly heterotrimeric introduce minimize mobility oncogenesis originates pairings pertussis photobleaching precoupling readouts specification uncoupling wnt
Tagcloud (Difference) ?		aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	10b 3a 5b 7a 9b affinities argues comprise dividing employ ethylmaleimide frap frizzled hardly heterotrimeric introduce minimize mobility oncogenesis originates pairings pertussis photobleaching precoupling readouts specification uncoupling wnt
Tagcloud (Intersection) ?