SFRP1 and FZD6

Number of citations of the paper that reports this interaction (PubMedID 10347172)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SFRP1	FZD6
Description		secreted frizzled related protein 1	frizzled class receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Apical Part Of Cell
	Molecular Function	Cysteine-type Endopeptidase Activity Frizzled Binding Protein Binding Heparin Binding Wnt-protein Binding Identical Protein Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Somitogenesis Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Regionalization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Neural Crest Cell Fate Commitment Wnt Signaling Pathway Neural Tube Development Hemopoiesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Osteoclast Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Development Of Primary Male Sexual Characteristics Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Stem Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Platelet Activation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Establishment Of Body Hair Planar Orientation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Midbrain Morphogenesis
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Anti-saccade response ( 29064472) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive astigmatism ( 30306274)	Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		8 interacting genes: FZD6 NHSL3 PPP1CA PPP1CC TMEM86B WNT1 WNT2 WNT4	3 interacting genes: CCDC88C SFRP1 WNT4
Entrez ID		6422	8323
HPRD ID		09165	04559
Ensembl ID		ENSG00000104332	ENSG00000164930
Uniprot IDs		Q8N474	B4DL33 B4E236 O60353
PDB IDs			8JH7 8JHB
Enriched GO Terms of Interacting Partners?		Cell Proliferation In Midbrain Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Frizzled Binding PTW/PP1 Phosphatase Complex Wnt Signaling Pathway Regulation Of Embryonic Development Mammary Gland Epithelium Development Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Cell Population Proliferation Neuron Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Embryonic Development Receptor Ligand Activity Tissue Morphogenesis Central Nervous System Neuron Differentiation Entrainment Of Circadian Clock By Photoperiod Morphogenesis Of A Branching Epithelium Protein Phosphatase 1 Binding Morphogenesis Of A Branching Structure Photoperiodism Entrainment Of Circadian Clock Cell Fate Commitment Developmental Induction Midbrain Development Dopaminergic Neuron Differentiation Cytokine Activity Branching Involved In Ureteric Bud Morphogenesis T Cell Differentiation In Thymus Cell Activation Non-canonical Wnt Signaling Pathway T Cell Activation Tube Morphogenesis Glycogen Metabolic Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Positive Regulation Of Fibroblast Proliferation Inner Ear Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis D-lysine 5,6-aminomutase Activity Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis	Frizzled Binding Non-canonical Wnt Signaling Pathway Wnt Signaling Pathway Female Gonad Development Positive Regulation Of Focal Adhesion Assembly Regulation Of Supramolecular Fiber Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Morphogenesis Of An Epithelium Kidney Epithelium Development Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cell-substrate Junction Organization Regulation Of Animal Organ Morphogenesis Regulation Of Stress Fiber Assembly Canonical Wnt Signaling Pathway Stem Cell Differentiation Positive Regulation Of Cell Junction Assembly Regulation Of Ossification Male Gonad Development Tube Formation Negative Regulation Of Cellular Response To Growth Factor Stimulus Convergent Extension Involved In Somitogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Gonad Development Regulation Of Osteoblast Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Supramolecular Fiber Organization Regulation Of Reproductive Process Regulation Of Organelle Organization Cellular Response To Starvation Nephron Morphogenesis Positive Regulation Of Glucocorticoid Biosynthetic Process
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