SFRP1 and KIAA1522

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SFRP1	KIAA1522
Gene Name		secreted frizzled-related protein 1	KIAA1522
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Drug Binding Heparin Binding Wnt-protein Binding Identical Protein Binding Wnt-activated Receptor Activity
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Dorsal/ventral Axis Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Neural Crest Cell Fate Commitment Response To Organic Cyclic Compound Menstrual Cycle Phase Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Rac GTPase Activity Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: FZD6 KIAA1522 PPP1CA WNT1 WNT2 WNT4	2 interactors: NCK1 SFRP1
Entrez ID		6422	57648
HPRD ID		09165	18852
Ensembl ID		ENSG00000104332	ENSG00000162522
Uniprot IDs		Q6ZSL4 Q8N474	Q9P206
PDB IDs
Enriched GO Terms of Interacting Partners?		Tissue Morphogenesis Positive Regulation Of Embryonic Development Tube Development Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Receptor Activity Wnt Signaling Pathway Positive Regulation Of Dermatome Development Developmental Induction Regulation Of Wnt Signaling Pathway Epithelium Development Epithelial Tube Morphogenesis Tube Morphogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Morphogenesis Of An Epithelium Regulation Of Embryonic Development Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Tissue Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anatomical Structure Morphogenesis Organ Morphogenesis Non-canonical Wnt Signaling Pathway Cell Fate Commitment Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryo Development Negative Regulation Of Signaling Organ Development Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Epithelial To Mesenchymal Transition Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Embryonic Organ Development Ureteric Bud Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gland Development Muscle Structure Development Nephron Morphogenesis	Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cytoskeleton Organization Convergent Extension Involved In Somitogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Menstrual Cycle Phase Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Transferase Activity Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Protein Phosphorylation Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Neural Crest Cell Fate Commitment Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neural Crest Formation Cellular Response To Heparin Axis Elongation Involved In Somitogenesis Regulation Of Cell Activation Regulation Of Cellular Ketone Metabolic Process Response To Heparin Cellular Response To X-ray Positive Regulation Of Fibroblast Apoptotic Process Regulation Of Cytoskeleton Organization Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of B Cell Differentiation Positive Regulation Of Cell Death Regulation Of Cell Adhesion Substrate-dependent Cell Migration, Cell Extension Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Cytoplasmic Translation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway
Tagcloud ?		aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 ligase lung mcm6 mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?		aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 ligase lung mcm6 mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?