SEMA3F and FBN2

Data Source: HiPPIP (Novel)

		SEMA3F	FBN2
Name		semaphorin 3F	fibrillin 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Glutamatergic Synapse	Microfibril Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Neural Crest Cell Migration Signal Transduction Axon Guidance Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Migration Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration System Development Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration
Pathways		None	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		None	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		None	Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Age at first birth ( 27089180 ) Age at first sexual intercourse ( 34211149 27089180 ) Body mass index ( 29273807 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) General cognitive ability ( 29844566 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma ( 31959993 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Intraocular pressure ( 31959993 29785010 ) Lateral thalamic nuclei volume ( 34006833 ) Mean platelet volume ( 32888494 ) Morning person ( 30696823 ) Multisite chronic pain ( 33830993 ) Refractive error ( 32231278 ) Regular attendance at a gym or sports club ( 29970889 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Sleep duration (short sleep) ( 30846698 ) Smoking initiation ( 33082346 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		7 interacting genes: NRP1 NRP2 SHBG SLC35G2 UBA1 UBC VEGFA	8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1
Entrez ID		6405	2201
HPRD ID		03079	00416
Ensembl ID		ENSG00000001617	ENSG00000138829
Uniprot IDs		C9JPG5 Q13275 Q59G50	P35556
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Ventral Trunk Neural Crest Cell Migration Neuropilin Signaling Pathway Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trunk Neural Crest Cell Migration Positive Regulation Of Axon Extension Involved In Axon Guidance Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Vascular Endothelial Growth Factor Receptor Activity Branchiomotor Neuron Axon Guidance Bone Trabecula Formation Hypothalamus Cell Migration Coronary Artery Morphogenesis Facial Nerve Structural Organization Sympathetic Ganglion Development Positive Regulation Of Endothelial Cell Proliferation Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Axon Extension Involved In Axon Guidance Motor Neuron Migration Semaphorin Receptor Activity Commissural Neuron Axon Guidance Positive Regulation Of Endothelial Cell Migration Semaphorin Receptor Complex Regulation Of Axon Extension Involved In Axon Guidance Ganglion Development Regulation Of Trophoblast Cell Migration Anatomical Structure Arrangement Neuron Migration Regulation Of Endothelial Cell Proliferation Retinal Ganglion Cell Axon Guidance Heparin Binding Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Motor Neuron Axon Guidance Outflow Tract Septum Morphogenesis Regulation Of Endothelial Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Epithelial Cell Proliferation Branching Involved In Blood Vessel Morphogenesis	Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity