SEMA3F and NRP2

Number of citations of the paper that reports this interaction (PubMedID 9883722)
0

Data Source:
HPRD (in vitro, in vivo)

		SEMA3F	NRP2
Description		semaphorin 3F	neuropilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Glutamatergic Synapse	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Axon Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Vascular Endothelial Growth Factor Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Signal Transduction Axon Guidance Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Migration Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration System Development Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development	Angiogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Nervous System Development Axon Guidance Heart Development Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways			Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs			ATYR1923
Diseases
GWAS		Age at first birth ( 27089180) Age at first sexual intercourse ( 34211149 27089180) Body mass index ( 29273807 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glaucoma ( 31959993) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 31959993 29785010) Lateral thalamic nuclei volume ( 34006833) Mean platelet volume ( 32888494) Morning person ( 30696823) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 30072576) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		7 interacting genes: NRP1 NRP2 SHBG SLC35G2 UBA1 UBC VEGFA	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		6405	8828
HPRD ID		03079	03643
Ensembl ID		ENSG00000001617	ENSG00000118257
Uniprot IDs		C9JPG5 Q13275 Q59G50	O60462
PDB IDs			2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT 7M22 7T4S 8IVW 8IVX
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Ventral Trunk Neural Crest Cell Migration Neuropilin Signaling Pathway Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trunk Neural Crest Cell Migration Positive Regulation Of Axon Extension Involved In Axon Guidance Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Vascular Endothelial Growth Factor Receptor Activity Branchiomotor Neuron Axon Guidance Bone Trabecula Formation Hypothalamus Cell Migration Coronary Artery Morphogenesis Facial Nerve Structural Organization Sympathetic Ganglion Development Positive Regulation Of Endothelial Cell Proliferation Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Axon Extension Involved In Axon Guidance Motor Neuron Migration Semaphorin Receptor Activity Commissural Neuron Axon Guidance Positive Regulation Of Endothelial Cell Migration Semaphorin Receptor Complex Regulation Of Axon Extension Involved In Axon Guidance Ganglion Development Regulation Of Trophoblast Cell Migration Anatomical Structure Arrangement Neuron Migration Regulation Of Endothelial Cell Proliferation Retinal Ganglion Cell Axon Guidance Heparin Binding Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Motor Neuron Axon Guidance Outflow Tract Septum Morphogenesis Regulation Of Endothelial Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Epithelial Cell Proliferation Branching Involved In Blood Vessel Morphogenesis	Semaphorin-plexin Signaling Pathway Chemotaxis Locomotion Neuron Projection Guidance Neuropilin Binding Semaphorin Receptor Binding Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Axon Guidance Neuron Projection Development Neural Crest Cell Migration Regulation Of Axonogenesis Mesenchymal Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Vascular Endothelial Growth Factor Signaling Pathway Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Regulation Of Axon Extension Chemorepellent Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Plasma Membrane Bounded Cell Projection Organization Negative Chemotaxis Ameboidal-type Cell Migration Regulation Of Neurogenesis Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Regulation Of Anatomical Structure Morphogenesis Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Developmental Growth Negative Regulation Of Axon Extension Ventral Trunk Neural Crest Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Binding Sympathetic Neuron Projection Guidance Neuropilin Signaling Pathway
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