FUT4 and ITGB2

Number of citations of the paper that reports this interaction (PMID 3305706)
18

Data Source:
HPRD (in vivo)

		FUT4	ITGB2
Gene Name		fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cell Surface Membrane Integral Component Of Membrane Golgi Cisterna Membrane Cell Periphery	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Fucosylation L-fucose Catabolic Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS		Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498)
Protein-Protein Interactions		3 interactors: CR1 ITGB2 SELP	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		2526	3689
HPRD ID		00083	02506
Ensembl ID		ENSG00000196371	ENSG00000160255
Uniprot IDs		P22083	A8MYE6 P05107
PDB IDs			1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Cellular Extravasation Positive Regulation Of Immune System Process Positive Regulation Of Serine-type Endopeptidase Activity Regulation Of Immune System Process Defense Response Selenium Compound Metabolic Process Negative Regulation Of Complement Activation, Alternative Pathway Leukocyte Migration Regulation Of Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Leukocyte Cell-cell Adhesion Complement Receptor Mediated Signaling Pathway Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Platelet Activation Inflammatory Response Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Regulation Of Integrin Activation Leukocyte Migration Involved In Inflammatory Response Single Organismal Cell-cell Adhesion Leukocyte Tethering Or Rolling Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Complement Activation Positive Regulation Of Immune Response Cell Activation Response To Wounding Heterotypic Cell-cell Adhesion Activated T Cell Proliferation Response To Stress Innate Immune Response Cell Migration Regulation Of Platelet Activation Regulation Of Immune Response Positive Regulation Of Blood Coagulation Regulation Of Complement Activation Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Nitric Oxide Biosynthetic Process Defense Response To Gram-negative Bacterium Negative Regulation Of Adaptive Immune Response Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Innate Immune Response Positive Regulation Of Coagulation Neutrophil Chemotaxis	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		a431 abolished akt asssociated carbohydrate catalyzes cdk correlates crosstalk difucosylated erk1 fucosyltransferase herein lewis ley ly294002 mapk mapks oligosaccharide p27 p38 pd98059 phosphoinositide pi3k prb promotes sb203580 upstream wortmannin	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		a431 abolished akt asssociated carbohydrate catalyzes cdk correlates crosstalk difucosylated erk1 fucosyltransferase herein lewis ley ly294002 mapk mapks oligosaccharide p27 p38 pd98059 phosphoinositide pi3k prb promotes sb203580 upstream wortmannin	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?