FUT4 and CR1

Number of citations of the paper that reports this interaction (PubMedID 3305706)
0

Data Source:
HPRD (in vivo)

		FUT4	CR1
Description		fucosyltransferase 4	complement C3b/C4b receptor 1 (Knops blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cell Surface Membrane Golgi Cisterna Membrane Cell Periphery	Extracellular Space Cytoskeleton Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity	Virus Receptor Activity Complement Binding Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Receptor Activity Complement Component C3b Receptor Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Protein O-linked Glycosylation Sphingolipid Metabolic Process Glycosphingolipid Biosynthetic Process Inflammatory Response Oligosaccharide Metabolic Process Oligosaccharide Biosynthetic Process Fucosylation L-fucose Catabolic Process Lymphocyte Migration Into Lymph Node Lewis X Epitope Biosynthetic Process Positive Regulation Of Neutrophil Migration Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes T Cell Mediated Immunity Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity ATP Export
Pathways		Lewis blood group biosynthesis	Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Small cell lung carcinoma ( 28604730)	Alzheimer's disease ( 21460840 31473137 19734903) Alzheimer's disease (late onset) ( 28714976 30617256 24162737 21460841) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)
Interacting Genes		3 interacting genes: CR1 ITGB2 SELP	6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		2526	1378
HPRD ID		00083	00398
Ensembl ID		ENSG00000196371	ENSG00000203710
Uniprot IDs		P22083	E9PDY4 P17927
PDB IDs			1GKG 1GKN 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
Enriched GO Terms of Interacting Partners?		Complement Component C3b Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane Raft Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Ficolin-1-rich Granule Membrane Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Immune System Process Integrin Binding Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Complement Component C4b Binding Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Negative Regulation Of Activation Of Membrane Attack Complex Defense Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Complement Activation, Alternative Pathway Immune Complex Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules ICAM-3 Receptor Activity Leukocyte Migration Positive Regulation Of Neutrophil Degranulation Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Complement Activation ATP Export Platelet Dense Granule Membrane Glycosphingolipid Binding Negative Regulation Of B Cell Differentiation Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Neutrophil Degranulation External Side Of Plasma Membrane Fucose Binding	Complement Activation, Classical Pathway Complement Activation Humoral Immune Response Symbiont Cell Surface Positive Regulation Of Immune System Process Immune Effector Process Regulation Of Complement Activation Activation Of Immune Response Defense Response Vertebrate Eye-specific Patterning Classical-complement-pathway C3/C5 Convertase Complex Cell Surface Innate Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Complement-mediated Synapse Pruning Regulation Of Immune System Process Defense Response To Symbiont Defense Response To Other Organism Immune System Process Complement Binding Positive Regulation Of Apoptotic Cell Clearance Regulation Of Immune Response Synapse Pruning Regulation Of Apoptotic Cell Clearance Response To Other Organism Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Neuron Remodeling Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Opsonization Response To External Biotic Stimulus Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Regulation Of Adaptive Immune Response Neuron Maturation Antigen Binding Endopeptidase Inhibitor Activity Positive Regulation Of Phagocytosis Virus Receptor Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Inflammatory Response Leukocyte Activation Positive Regulation Of Activation Of Membrane Attack Complex
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