SELPLG and GALNT4

Number of citations: 0 (PubMedID 9804815)
Data Source: HPRD (in vitro)

		SELPLG	GALNT4
Name		selectin P ligand	polypeptide N-acetylgalactosaminyltransferase 4
Structure
GO Annotations	Cellular Component	Uropod Plasma Membrane Membrane Plasma Membrane Raft	Golgi Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Cell Adhesion Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Cell surface interactions at the vascular wall	O-linked glycosylation of mucins
Drugs		Neihulizumab	None
GWAS		Acne (severe) ( 24927181 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Conduct disorder (symptom count) ( 20585324 )	B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677 ) NT-proBNP levels in acute coronary syndrome ( 26908625 )
Interacting Genes		14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN	2 interacting genes: MUC1 SELPLG
Entrez ID		6404	8693
HPRD ID		02845	09152
Ensembl ID		ENSG00000110876	ENSG00000257594
Uniprot IDs		Q14242	Q8N4A0
PDB IDs		1G1S	5NQA 6H0B
GO Terms Enriched among Interactors		Leukocyte Cell-cell Adhesion Leukocyte Migration Oligosaccharide Binding Carbohydrate Binding Leukocyte Tethering Or Rolling Sialic Acid Binding Protein-tyrosine Sulfotransferase Activity Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Glycosphingolipid Binding Regulation Of Platelet Activation Cell Motility Positive Regulation Of Leukocyte Tethering Or Rolling Regulation Of Leukocyte Tethering Or Rolling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Response To Lipopolysaccharide Immune System Process Phospholipase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Response To Molecule Of Bacterial Origin Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Neutrophil Activation Positive Regulation Of Receptor Internalization Regulation Of Platelet Aggregation Regulation Of Leukocyte Cell-cell Adhesion Heparin Binding Regulation Of Immune System Process Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Innate Immune Response-activating Signaling Pathway Trans-Golgi Network Signaling Receptor Ligand Precursor Processing Response To Lipid Biofilm Matrix Disassembly Regulation Of Defense Response Mevalonate Kinase Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Peptidyl-tyrosine Sulfation Golgi-associated Vesicle Lumen Activation Of Innate Immune Response Response To External Biotic Stimulus	Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Adhesive Activation Response To Interleukin-6 Uropod Leukocyte Tethering Or Rolling Cellular Response To Interleukin-6 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Plasma Membrane Raft DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Signal Transduction By P53 Class Mediator Leukocyte Cell-cell Adhesion Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G1/S Phase Transition P53 Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling